Interfacial Cocrystallization Using Oily Phase via Liquid-Liquid Phase Separation

Cocrystals consist of two molecules bonded together in a single crystal lattice giving rise to wide applications including improving solubility of poorly soluble pharmaceuticals. Cocrystallization reaction occurs in the oily phase of liquid-liquid phase separation (LLPS) after it is mixed with coformers. Indomethacin- saccharin cocrystal formation was monitored in situ, and the kinetics of crystallization were determined. The crystallization rates show that the process can be proposed to prevent unwanted oily phase formation during LLPS.

Automated summary

Cocrystals, formed by the bonding of two molecules in a single crystal lattice, have wide applications in improving the solubility of poorly soluble pharmaceuticals. The study shows that the cocrystallization reaction can prevent the formation of unwanted oily phase during liquid-liquid phase separation.