4.7 Review

A biochemical perspective on the fate of virgin olive oil phenolic compounds in vivo

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Summary: The modulation of gut microbiota by polyphenols from olives and derived products is of increasing interest. In this study, phenolic leaf extracts (PLE) were in vitro fermented to evaluate changes in phenolic profiles and their impact on microbiota. The fermentation of PLE decreased oleuropein content and increased hydroxytyrosol and other phenolic metabolites. A significant increase in hydroxytyrosol was also observed in fermented extra-virgin olive oil (EVOO). The fermentation of PLE also significantly changed the amino acids and fatty acids profile of the faeces. Metagenomic sequencing revealed that Coriobacteriaceae at the family level and Collinsella at the genus level were the most affected by PLE fermentation.

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Summary: This study presents an efficient method for the recovery and purification of phenolic compounds from extra virgin olive oil on a pilot scale, involving liquid-liquid extraction and chromatographic techniques. Special attention was paid to the selection of raw materials and purification of target compounds, resulting in the isolation of new natural products as well as the description of a novel constituent in EVOO.

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Summary: The Mediterranean diet is rich in antioxidants and anti-inflammatory nutrients, with extra-virgin olive oil playing a key role due to its phenolic compounds and secoiridoids. These compounds have been shown to have antioxidant, anti-inflammatory, and anti-proliferative properties, which contribute to their anti-cancer activity. The review summarizes the pharmacological properties, molecular targets, and action mechanisms of secoiridoids, with a focus on their potential use in cancer prevention and treatment.

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A New Definition of the Term High-Phenolic Olive Oil Based on Large Scale Statistical Data of Greek Olive Oils Analyzed by qNMR

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Summary: A study conducted in Greece analyzed 5764 olive oil samples from over 30 varieties over an eleven-year period, with the aim of measuring the phenolic content using qNMR. The results showed significant variation in phenolic content among different olive oil cultivars, with an average total phenolic content of 483 mg/kg and a maximum recorded concentration of 4003 mg/kg. The study proposed defining "high-phenolic" and "exceptionally high-phenolic" olive oil based on phenolic content levels.

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Summary: Oleacein (OLEA) is a key phenolic compound in extra virgin olive oil with high concentration and health-promoting properties. Research shows that it is well absorbed in the intestine with significant intestinal first-pass effect.

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