Recent progress in the construction and applications of metal-organic frameworks and covalent-organic frameworks-based nanozymes

Nanozymes, a kind of catalytic nanomaterials with enzymatic catalytic properties, have attracted immense interests in recent years owing to their high stability and low cost. Among a variety of materials served as nanozymes, metal-organic frameworks (MOFs) and covalent-organic frameworks (COFs) as emerging organic framework materials have gained increasing attention due to their high surface area and flexible nano-scale porosity, which can be rationally designed to own ideal mimic enzyme activities. In this review, MOFs-based and COFs-based nanozymes have been introduced from the aspects of construction and composition. Besides, the applications in sensing and therapy have been summarized. Finally, the development status, current challenges and future prospect on the MOFs and COFs-based nanozymes were briefly discussed, so as to promote the wider applications. (C) 2022 Elsevier B.V. All rights reserved.

Automated summary

Nanozymes, a type of catalytic nanomaterials with enzymatic properties, have gained significant interest in recent years due to their stability and cost-effectiveness. Metal-organic frameworks (MOFs) and covalent-organic frameworks (COFs) as emerging organic framework materials have attracted attention for their high surface area and flexible nano-scale porosity, which can be designed to mimic ideal enzyme activities. This review introduces MOFs-based and COFs-based nanozymes, discusses their construction and composition, summarizes their applications in sensing and therapy, and briefly discusses the current development status, challenges, and future prospects of MOFs and COFs-based nanozymes to promote wider applications.