期刊
CONTRAST MEDIA & MOLECULAR IMAGING
卷 2022, 期 -, 页码 -出版社
WILEY-HINDAWI
DOI: 10.1155/2022/8382295
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This study investigates the efficacy and safety of BGF in the treatment of COPD. The results show that BGF can improve the lung function of COPD patients, but its effects on adverse event rates, mortality rate, and hypertension incidence rate are not significant.
Objective. Chronic obstructive pulmonary disease (COPD) is a major and difficult disease of the chronic respiratory system that is common and frequent, with a huge disease burden. The aim of this study was to investigate the efficacy and safety of budesonide/glyburide/formoterol fumarate (BGF) in the treatment of COPD. Methods. A comprehensive literature search was conducted in PubMed, Embase, Cochrane Library, and Web of Science. The basic features of the seven pieces of literature were identified using the search strategy. The sample size range was 130 similar to 1264. Results. The effects of BGF increased FEV1 in patients with COPD (mean difference=2.86, 95%CI: 2.71-3.01, p<0.00001). The effects of BGF improved in patients with 1 TEAE in patients with COPD, and was not statistically significant after treatment (Odds rate=1.00, 95%CI: 0.85-1.17, p=0.97). The effects of BGF increased in patients with TEAEs related a to study treatment in patients with COPD (odds rate=1.27, 95% CI: 1.03-1.57, p=0.02). The effects of BGF in decreased patients with serious TEAEs in patients with COPD (odds rate=-0.02, 95% CI: -0.03--0.00, p=0.04). The effects of BGF decreased the death rate in patients with COPD, and were not statistically significant after treatment (odds rate=0.77, 95% CI: 0.31-1.97, p=0.59). The effects of BGF decreased the hypertension rate in patients with COPD (odds rate=0.92, 95% CI: 0.44-1.89, p=0.81), and was not statistically significant after treatment. The effects of BGF increased pneumonia in patients with COPD (odds rate=1.55, 95% CI: 0.81-2.97, p=0.19), and were not statistically significant after treatment. The effects of BGF increased FEV1, increased patients with TEAEs related a to study treatment, and decreased patients with serious TEAEs in patients with COPD. Conclusion. This study elucidates the efficacy and safety of BGF in the treatment of COPD with a view to providing a clinical reference.
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