Framework of sampling the subject-specific static loads from the gait cycle of interindividual variation

Background and Objective: Numerous techniques for bone remodeling simulation have been developed based on Wolff's law. However, most studies have been conducted with empirically determined static loads, which cannot reflect subject-specific characteristics. We recently proposed a new concept of repre-sentative static loads (RSLs) to efficiently consider the effect of cyclically repeated dynamic loads on bone remodeling simulation. Based on this concept, the goal of this study is to sample the subject-specific static loads (SSL) from a general gait cycle of interindividual variation.Methods: A total of 15 gait cycles (ten normal and five abnormal cycles) obtained from the public database were used in this study. Each gait cycle was applied to a femur FE model constructed from the clinical CT scan data to evaluate the strain energy distribution as a reference. Then, a natural coor-dinate was introduced to maintain the predefined locations of extreme points (i.e., two peaks and one valley) for both normal and abnormal gait cycles. To determine the RSLs in the natural coordinate, five out of ten normal gait cycles were used. Through an inverse transformation for each gait cycle, the RSLs in the natural coordinate were converted to the SSLs in the original coordinate. Topology optimization results with the proposed SSLs were compared with those with a single full gait cycle (reference). For comparison, topology optimization was also conducted with empirically determined loads (EDLs) which have been widely used in the literature.Results: For normal gait cycles, the proposed SSLs reduced the average computing cost by 95.86% while suppressing the errors of bone mass distribution and apparent stiffness below maximum 4.24% and 1.72%, respectively. Even for abnormal gait cycles, the errors of bone mass distribution and apparent stiffness were suppressed below maximum 9.49% and 2.12%, respectively. Conversely, the conventional EDLs (peak loads selected in this study) showed significantly larger errors of maximum 47.28% and 30.31% in bone mass distribution and apparent stiffness for normal gait cycles.Conclusion: By virtue of using the coordinate transformation for each gait cycle, the proposed SSLs achieved a higher accuracy in the bone mass distribution and apparent stiffness than the previous RSLs and EDLs. Furthermore, this approach can be used for abnormal gait cycles which have higher interindi-vidual variation.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

The study proposed representative static loads (RSLs) based on a general gait cycle to improve bone remodeling simulation accuracy. By sampling subject-specific static loads (SSL) from RSLs, the study reduced computing cost and errors in bone mass distribution and apparent stiffness.