Recent Developments in the MCRs Synthesis of Pyridopyrimidines and Spiro-Pyridopyrimidines

Because of biological and medicinal properties of pyridopyrimidines, synthesis of these heterocycles has attracted the interest of organic and medicinal chemists. This review focuses on the recent development in the multi-component synthesis of pyridopyrimidine and spiro-conjugated pyridopyrimidine systems. The present review describes the literature reports for the period 2000-2015, particularly those that involve the reactions of activated methylene, aldehyde or ketone, and amine in classical and nonclassical conditions.