期刊
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
卷 117, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.cnsns.2022.106966
关键词
-
In this study, the authors compare two popular computational models, the phase-field model and the coarse-grained model, in characterizing cell morphologies, adhesion, and stiffness in a real C. elegans embryo. They find that the phase-field model is superior in capturing cell shapes and inferring cell stiffness. They also demonstrate that the phase-field model converges to the coarse-grained model under certain conditions, obtaining an isotropic intercellular force.
Embryonic development is a precise and complex process involving the cell mor-phology and mechanics interacting in space and time. The difficulty in quantitatively acquiring cellular morphological and mechanical information in vivo makes mathe-matical modeling a challenging problem and impedes model validation. Recently, the three-dimensional time-lapse live imaging and delineated developmental programs in the roundworm Caenorhabditis elegans provide an excellent platform for establishing quantitative models. In this paper, we study two popular computational models for multicellular systems, i.e., the phase-field model and the coarse-grained model, and compare their performance in characterizing the cell morphologies, cell adhesion, and cell stiffness in a real C. elegans embryo. We show that both models can capture cell-cell contact areas and heterogeneous cell adhesion, but only the phase-field model succeeds in inferring the heterogeneous cell stiffness by fitting cell shapes or cell-cell interface curvatures. Moreover, we demonstrate that the phase-field model converges to the coarse-grained model when increasing cell surface tension to dominance, obtaining a distance-dependent isotropic intercellular force.(c) 2022 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据