Fabrication of strontium carbonate-based composite bioceramics as potential bone regenerative biomaterials

Strontium carbonate (SrC) bioceramics are proposed as potential biomaterials to efficaciously repair the bone defects. However, the development of SrC bioceramics is restricted by their intrinsic low mechanical strength. In this study, SrC-based composite bioceramics (SrC-SrP) were fabricated by incorporating strontium-containing phosphate glass (SrP). The results indicated that aside from the main crystalline phase SrC, new compounds were generated in the SrC-SrP bioceramics. Incorporating 10 wt% SrP promoted densification, thus dramatically improving compressive strength of SrC-SrP bioceramics. The SrC-SrP bioceramics facilitated apatite precipitation on their surface, and sustainedly released strontium, phosphorus and sodium ions. Compared with the wellknown 8-tricalcium phosphate bioceramics, the SrC-SrP bioceramics with certain amounts of SrP enhanced proliferation, alkaline phosphatase activity and osteogenesis-related gene expressions of mouse bone mesenchymal stem cells. The SrC-SrP bioceramics with appropriate constituent can serve as novel bone regenerative biomaterials.

Automated summary

In this study, composite bioceramics containing strontium-containing phosphate glass (SrP) were fabricated to improve the mechanical strength of strontium carbonate (SrC) bioceramics. The addition of 10 wt% SrP promoted densification, enhanced compressive strength, and facilitated apatite precipitation and sustained ion release. The SrC-SrP bioceramics showed better proliferation and osteogenesis effects on bone cells compared to traditional bioceramics.