期刊
JOURNAL OF HETEROCYCLIC CHEMISTRY
卷 54, 期 1, 页码 384-390出版社
WILEY
DOI: 10.1002/jhet.2594
关键词
-
资金
- research council of Tehran University of Medical Sciences [92-03-33-24363]
In this work, a wide range of novel pyrazolo[4',3':5,6] pyrano[2,3-b] quinolin-5-amines were synthesized as tacrine analogs. At first, reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, aromatic aldehydes, and malononitrile gave 6-amino-4-aryl-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles. Then, reaction of the latter compounds with cyclohexanone led to the formation of the title compounds. Also, they were evaluated for their in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activities. Interestingly, most of them showed good inhibitory activity comparing with rivastigmine as the reference drug.
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