4.7 Article

Invisible assassin coated on dental appliances for on-demand capturing and killing of cariogenic bacteria

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出版社

ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112696

关键词

Invisible assassin; Antifouling; On -demand anti -bacteria; pH responsive; Dental appliances

资金

  1. National Natural Science Foundation of China [51925304, 51973133, 51903175]
  2. Sichuan Science and Technology Program [2020YJ0024]

向作者/读者索取更多资源

This article introduces a smart antibacterial material for combating dental caries, which can resist microbial invasion and eliminate cariogenic bacteria under acidic conditions. The material is biocompatible, transparent, stable, and has minimal impact on the aesthetics and mechanical properties of the bulk material.
The accumulation of microbes on long-wear artificial dental materials creates a great risk for oral diseases and causes deterioration of material properties. Therefore, smart antibacterial materials capable of resisting the colonization of microorganisms and simultaneously eliminating pathogenic bacteria as needed show outstanding superiority for the recovery of dental health, which are scarcely reported until now. Here, we present a responsive hydrogel coating as invisible assassin on clear overlay appliances target for dental caries. Taking advantage of pH-responsive carboxybetaine methacrylate-dimethylaminoethyl methacrylate copolymer P (CBMA-co-DMAEMA) and antibacterial peptides, the surface potential of hydrogel shifts positively, accompanied with the release of antibacterial peptides when pH gets lower. The hybrid hydrogel layer hence exerts antifouling property and resists bacterial adhesion in normal physiological, while captures and kills cariogenic bacteria in acidic condition. This biocompatible, transparent and stable hydrogel coating has little influence for the aesthetics and mechanical properties of bulk materials. The strategy developed here can provide reference for the design of biomedical devices in other areas.

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