Synthesis and Anti-influenza Virus Activity of Novel bis(4H-chromene-3-carbonitrile) Derivatives

An efficient and convenient method for the synthesis of bis(4H-chromene-3-carbonitrile) derivatives by one-pot, multicomponent reaction of bis-aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine is reported. Bis(2-benzylidene-1H-indene)-1,3-(2H)-dione derivatives were obtained as the main products as a result of reaction of the bis(arylidenemalononitriles) with indandione. The anti-influenza H5N1 virus activities of the newly prepared bis-chromene derivatives are also investigated.