期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 650, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2022.129631
关键词
Stimuli -responsive hydrogel; Self -healable gel; Drug release; Fe 2 O 3 nanoparticles; Density functional theory calculations
资金
- Department of Science and Technology (DST) , India [IF170625]
- SERB-DST ECR Project [ECR/2016/001289]
- Parul University, Vadodara
In this study, a highly efficient drug uptake and delivery system was developed using an amphiphilic hybrid hydrogel based on a poly (ethylene glycol)-block-poly(propyleneglycol)-block-poly(ethylene glycol) (Pluronic P123) and choline acetate ionic liquid (IL). The resulting hydrogel exhibited biodegradable, stimuli-responsive, biocompatible, and self-healing characteristics. First-principles-based density functional theory calculations provided insights into the intermolecular interactions involved in the formation of the hybrid hydrogel.
Hydrogels are three-dimensional solid-like substances that can expand to a large extent while retaining their three-dimensional hierarchical structure. Owing to their superior qualities of high-water content, biocompati-bility, degradations, and flexibility, they are attracting a lot of interest for their potential applications as topical drug administration in the form of thin films and as drug carrier vehicles. In this study, we developed a poly (ethylene glycol)-block-poly(propyleneglycol)-block-poly(ethylene glycol) (Pluronic P123)-based amphiphilic hybrid hydrogel using choline acetate ionic liquid (IL) and additional biocompatible components such as agar, glycerol, and sodium tetraborate. The resulting hybrid hydrogel loaded with iron oxide nanoparticles (NPs) was found to be a highly efficient system for drug uptake and delivery which exhibits biodegradable, stimuli -responsive, biocompatible as well as self-healing characteristics. First-principles-based density functional the-ory (DFT) calculations provide greater insights into the nature of intermolecular interactions participating in the formation of the hybrid hydrogel, as confirmed by infrared spectroscopy. With their enormous amenability to modification, prepared hydrogel serves as a promising delivery vehicle of diclofenac sodium (DS) drugs for anti-inflammatory drug delivery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据