期刊
CNS NEUROSCIENCE & THERAPEUTICS
卷 28, 期 11, 页码 1663-1674出版社
WILEY
DOI: 10.1111/cns.13948
关键词
crosstalk; health; microglia; NG2-glia; sickness
资金
- National Natural Science Foundation of China [81770806]
- Natural Science Foundation of Chongqing [cstc2021jcyj--msxmX0249]
- Special Project for Enhancing Science and Technology Innovation Ability of Army Military Medical University [2019XYY16]
This review provides an overview of the interaction between NG2-glia and microglia in neurodegenerative diseases. It highlights the influence of these cells on each other's survival and function, and emphasizes the importance of understanding this interaction for modulating myelination and treating neurodegenerative disorders.
Neurodegenerative diseases are increasingly becoming a global problem. However, the pathological mechanisms underlying neurodegenerative diseases are not fully understood. NG2-glia abnormalities and microglia activation are involved in the development and/or progression of neurodegenerative disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and cerebrovascular diseases. In this review, we summarize the present understanding of the interaction between NG2-glia and microglia in physiological and pathological states and discuss unsolved questions concerning their fate and potential fate. First, we introduce the NG2-glia and microglia in health and disease. Second, we formulate the interaction between NG2-glia and microglia. NG2-glia proliferation, migration, differentiation, and apoptosis are influenced by factors released from the microglia. On the other hand, NG2-glia also regulate microglia actions. We conclude that NG2-glia and microglia are important immunomodulatory cells in the brain. Understanding the interaction between NG2-glia and microglia will help provide a novel method to modulate myelination and treat neurodegenerative disorders.
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