期刊
CLINICAL SCIENCE
卷 136, 期 18, 页码 1371-1387出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20220175
关键词
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资金
- Ariane de Rothschild Women Doctoral Program
- Nehemia Levtzion Scholarship for Outstanding Doctoral Students
- Leona M. and Harry B. Helmsley Charitable Trust
- Adelis Foundation
- Ben B. and Joyce E. Eisenberg Foundation
- Estate of Bernard Bishin for the WIS-Clalit Program
- Jeanne and Joseph Nissim Center for Life Sciences Research
- Miel de Botton
- Swiss Society Institute for Cancer Prevention Research
- Belle S. and Irving E. Meller Center for the Biology of Aging
- Sagol Institute for Longevity Research
- Sagol Weizmann-MIT Bridge Program
- Norman E Alexander Family M Foundation Coronavirus Research Fund
- Mike and Valeria Rosenbloom Foundation
- Daniel Morris Trust
- Isidore and Penny MyersFoundation
- Vainboim Family
- European Research Council
- Israel Science Foundation
- Israel Ministry of Science and Technology
- Israel Ministry of Health
- German-Israeli Helmholtz International Research School: Cancer-TRAX
- Helmholtz Association's Initiative and Networking Fund
- Minerva Foundation
- Garvan Institute
- European Crohn's and Colitis Organization
- Deutsch-Israelische Projektkooperation
- IDSA Foundation
- WIS-MIT grant
- Charlie Teo Foundation
- Mark Foundation for Cancer Research
- Welcome Trust
- [HIRS-0003]
Smoking is associated with increased risks of cancer, pulmonary and cardiovascular diseases, and it can impact the composition and function of the microbiome in various parts of the body. Understanding the role of the microbiome can aid in developing rational therapies for smoking-related diseases and smoking cessation.
Smoking is associated with an increased risk of cancer, pulmonary and cardiovascular dis-eases, but the precise mechanisms by which such risk is mediated remain poorly under-stood. Additionally, smoking can impact the oral, nasal, oropharyngeal, lung and gut micro-biome composition, function, and secreted molecule repertoire. Microbiome changes in-duced by smoking can bear direct consequences on smoking-related illnesses. Moreover, smoking-associated dysbiosis may modulate weight gain development following smoking cessation. Here, we review the implications of cigarette smoking on microbiome community structure and function. In addition, we highlight the potential impacts of microbial dysbiosis on smoking-related diseases. We discuss challenges in studying host-microbiome inter-actions in the context of smoking, such as the correlations with smoking-related disease severity versus causation and mechanism. In all, understanding the microbiome's role in the pathophysiology of smoking-related diseases may promote the development of ratio-nal therapies for smoking-and smoking cessation-related disorders, as well as assist in smoking abstinence.
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