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Response to Rowland et al. and Achour et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

Liquid Biopsy for Patient Characterization in Cardiovascular Disease: Verification against Markers of Cytochrome P450 and P-Glycoprotein Activities

Brahim Achour et al.

Summary: Precision dosing strategies require considering individual variability in pharmacokinetics and pharmacodynamics. Liquid biopsy is a valuable new approach for early disease diagnosis. This study aimed to verify the correlation between expression measurements of certain enzymes and transporters in liquid biopsy with genotype and activity phenotype. Verifying liquid biopsy against activity phenotype is important for individualized modeling approaches.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Article Pharmacology & Pharmacy

Liquid Biopsies or Therapeutic Drug Monitoring for CYP Activity Profile Determination

Chris S. Pridgeon et al.

Summary: This study validated the use of liquid biopsy-based quantification of cfRNA in plasma exosomes as a proxy measurement for predicting hepatic CYP gene expression and drug metabolism rate, but the correlations were too weak to be a reliable substitute for therapeutic drug monitoring (TDM).

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Article Pharmacology & Pharmacy

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

Brahim Achour et al.

Summary: Variability in hepatic drug metabolism and disposition is well recognized, and this study successfully developed a liquid biopsy technology for assessing individual patient's capacity. The technology showed reliable patient stratification and utility in adjusting drug dose for achieving similar drug exposure between patients with variable hepatic elimination.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Article Chemistry, Medicinal

Post-Translational Regulation of CYP450s Metabolism As Revealed by All-Atoms Simulations of the Aromatase Enzyme

Ida Ritacco et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)

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Response to Rowland et al. and Achour et al.

相关参考文献

Liquid Biopsy for Patient Characterization in Cardiovascular Disease: Verification against Markers of Cytochrome P450 and P-Glycoprotein Activities

Liquid Biopsies or Therapeutic Drug Monitoring for CYP Activity Profile Determination

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

Post-Translational Regulation of CYP450s Metabolism As Revealed by All-Atoms Simulations of the Aromatase Enzyme

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