期刊
CLINICAL NUTRITION
卷 41, 期 11, 页码 2565-2576出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2022.09.012
关键词
Gut microbiome; Cogitative aging; Psychobiotics; Lactobacillus rhamnosus GG; Prevotella
资金
- Center for Gastrointestinal Biology and Disease [CGIBD P30 DK034987]
- UNC Nutrition Obesity Research Center [N ORC P30DK056350]
- I-Health, Inc., a division of Royal DSM
This study investigated the gut microbiome composition and predicted microbial functional pathways of middle-aged and older adults with mild cognitive impairment (MCI), compared to neurologically healthy individuals. The impact of probiotic Lactobacillus rhamnosus GG (LGG) on cognitive performance was also examined. The results identified specific taxa correlated with MCI and showed that supplementation with LGG improved cognitive scores.
Background: Advancing age coincides with changes in the gut microbiome and a decline in cognitive ability. Psychobiotics are microbiota-targeted interventions that can result in mental health benefits and protect the aging brain. This study investigated the gut microbiome composition and predicted microbial functional pathways of middle-aged and older adults that met criteria for mild cognitive impairment (MCI), compared to neurologically healthy individuals, and investigated the impact of probiotic Lactobacillus rhamnosus GG (LGG) in a double-blind, placebo-controlled, randomized clinical trial. A total of 169 community-dwelling middle-aged (52-59 years) and older adults (60-75 years) received a three-month intervention and were randomized to probiotic and placebo groups. Participants were further subdivided based on cognitive status into groups with intact or impaired cognition and samples were collected at baseline and post supplementation. Results: Microbiome analysis identified Prevotella ruminicola, Bacteroides thetaiotaomicron, and Bacteroides xylanisolvens as taxa correlated with MCI. Differential abundance analysis at baseline identified Prevotella as significantly more prevalent in MCI subjects compared to cognitively intact subjects (ALDEx2 P = 0.0017, ANCOM-BC P = 0.0004). A decrease in the relative abundance of the genus Prevotella and Dehalobacterium in response to LGG supplementation in the MCI group was correlated with an improved cognitive score. Conclusions: Our study points to specific members of the gut microbiota correlated with cognitive performance in middle-aged and older adults. Should findings be replicated, these taxa could be used as key early indicators of MCI and manipulated by probiotics, prebiotics, and symbiotics to promote successful cognitive aging. (c) 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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