☆ 4.6 Editorial Material

203Pb-VMT-α-NET Scintigraphy of a Patient With Neuroendocrine Tumor

CLINICAL NUCLEAR MEDICINE (2023)

A Physiologically Based Pharmacokinetic Model for In Vivo Alpha Particle Generators Targeting Neuroendocrine Tumors in Mice

Nouran R. R. Zaid et al.

Summary: The study developed a murine whole-body PBPK model for Pb-212-SSTA, finding that alpha-PRRT based on Pb-212-SSTA results in lower absorbed doses in non-target tissues compared to Bi-212-SSTA. The model demonstrates that the majority of energy release in the kidneys occurs in the glomeruli and proximal tubules.

PHARMACEUTICS (2021)

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Article Oncology

Targeted Alpha-Particle Radiotherapy and Immune Checkpoint Inhibitors Induces Cooperative Inhibition on Tumor Growth of Malignant Melanoma

Mengshi Li et al.

Summary: The study demonstrated the feasibility of delivering alpha-particle radiation to murine melanoma tumors using a radiolabeled peptide that targets the melanocortin 1 receptor. The combination of targeted alpha-particle radionuclide therapy and immune checkpoint inhibitors showed significant anti-tumor cooperation in preclinical models of melanoma, mediated by induction of tumor-specific immunity.

CANCERS (2021)

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Review Biochemistry & Molecular Biology

203/212Pb Theranostic Radiopharmaceuticals for Image-guided Radionuclide Therapy for Cancer

Mengshi Li et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Development and dosimetry of 203Pb/212Pb-labelled PSMA ligands: bringing the lead into PSMA-targeted alpha therapy?

Jose Carlos dos Santos et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2019)

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Article Chemistry, Inorganic & Nuclear

Automated cassette-based production of high specific activity [203/212pb] peptide-based theranostic radiopharmaceuticals for image-guided radionuclide therapy for cancer

Mengshi Li et al.

APPLIED RADIATION AND ISOTOPES (2017)

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Article Radiology, Nuclear Medicine & Medical Imaging

Twins in spirit - episode I: comparative preclinical evaluation of [68Ga]DOTATATE and [68Ga]HA-DOTATATE

Margret Schottelius et al.

EJNMMI RESEARCH (2015)

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Article Biochemical Research Methods

Improvement of pharmacokinetics of radioiodinated Tyr3-octreotide by conjugation with carbohydrates

M Schottelius et al.

BIOCONJUGATE CHEMISTRY (2002)

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203Pb-VMT-α-NET Scintigraphy of a Patient With Neuroendocrine Tumor

相关参考文献

A Physiologically Based Pharmacokinetic Model for In Vivo Alpha Particle Generators Targeting Neuroendocrine Tumors in Mice

Targeted Alpha-Particle Radiotherapy and Immune Checkpoint Inhibitors Induces Cooperative Inhibition on Tumor Growth of Malignant Melanoma

203/212Pb Theranostic Radiopharmaceuticals for Image-guided Radionuclide Therapy for Cancer

Development and dosimetry of 203Pb/212Pb-labelled PSMA ligands: bringing the lead into PSMA-targeted alpha therapy?

Automated cassette-based production of high specific activity [203/212pb] peptide-based theranostic radiopharmaceuticals for image-guided radionuclide therapy for cancer

Twins in spirit - episode I: comparative preclinical evaluation of [68Ga]DOTATATE and [68Ga]HA-DOTATATE

Improvement of pharmacokinetics of radioiodinated Tyr3-octreotide by conjugation with carbohydrates

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