期刊
CLINICAL NEUROPHYSIOLOGY
卷 141, 期 -, 页码 53-61出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2022.06.014
关键词
Bipolar disorder; Electroencephalography; Magnetoencephalography; Gamma rhythm; Meta -analysis; Systematic review
资金
- Health Research Foun-dation of Central Denmark Region [R64-A3090-B1898]
- Lundbeck Foundation [R322-2019-2311]
This study explored the evidence of 40-Hz ASSR deficits in patients with bipolar disorder, and found consistent reductions in 40-Hz ASSR evoked power and inter-trial phase coherence compared with healthy controls. Further large-scale studies are needed to link 40-Hz ASSR deficits to clinical features and developmental trajectories.
Objective: Bipolar disorder is characterized by aberrant neurophysiological responses as measured with electroencephalography (EEG) and magnetoencephalography (MEG), including the 40-Hz auditory steady-state response (ASSR). 40-Hz ASSR deficits are also found in patients with schizophrenia and may represent a transdiagnostic biomarker of neuronal circuit dysfunction. In this systematic review and meta-analysis, we summarize and evaluate the evidence for 40-Hz ASSR deficits in patients with bipolar disorder.Methods: We identified studies from PubMed, EMBASE, and SCOPUS. We assessed the risk of bias, calculated Hedges' g meta-level effect sizes, and investigated small-study effects using funnel plots and Egger regression.Results: Seven studies, comprising 396 patients with bipolar disorder and 404 healthy controls, were included in the meta-analysis. Studies displayed methodological heterogeneity and an overall high risk of bias. Patients with bipolar disorder showed consistent reductions in 40-Hz ASSR evoked power (Hedges' g = -0.49; 95% confidence intervals [-0.67, -0.31]) and inter-trial phase coherence (ITPC) (Hedges' g = -0.43; 95 %CI [-0.58, -0.29]) compared with healthy controls.Conclusions: Our meta-analysis provides evidence that 40-Hz ASSRs are reduced in patients with bipolar disorder compared with healthy controls.Significance: Future large-scale studies are warranted to link 40-Hz ASSR deficits to clinical features and developmental trajectories.(c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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