期刊
JOURNAL OF HEPATOLOGY
卷 64, 期 -, 页码 S71-S83出版社
ELSEVIER
DOI: 10.1016/j.jhep.2016.01.026
关键词
Antiviral immunity; B lymphocytes; T lymphocytes; Immunodominance; T cell exhaustion
资金
- Singapore Translational Research (STaR) Investigator Award [NMRC/STaR/013/2012]
- Translational Research Grant from the National Medical Research Council Singapore [NMRC/TCR/014/NUHS-2015]
- Regione Emilia-Romagna, Italy [PRUa1RI-2012-006]
- Programma di Ricerca Regione-University
- Fondazione Cassa di Risparmio di Parma, Italy
- FIRB grant from the Italian Ministry of the University and Research [RBAP10TPXK]
During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately determines HBV infection outcome. In this review, in addition to summarizing the present state of knowledge of HBV-adaptive immunity, we will highlight controversies and uncertainties concerning the HBV-specific B and T lymphocyte response, and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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