期刊
CLINICAL GENETICS
卷 103, 期 2, 页码 133-145出版社
WILEY
DOI: 10.1111/cge.14232
关键词
assisted reproductive technology; epigenetic modifications; genetic; imprinting disorders; in vitro fertilization; infertility; intracytoplasmic sperm injection; offspring health
Assisted reproductive technology may have an impact on the epigenome of embryos, but the extent of this influence is not yet clear. Concerns have been raised about the increased occurrence of epigenetic anomalies and imprinting following assisted reproductive technology. The periconceptional period is particularly vulnerable to environmental conditions, and various factors in assisted reproductive technology have the potential to disrupt epigenetic regulation.
Assisted reproductive technology may influence epigenetic signature as the procedures coincide with the extensive epigenetic modification occurring from fertilization to embryo implantation. However, it is still unclear to what extent ART alters the embryo epigenome. In vivo fertilization occurs in the fallopian tube, where a specific and natural environment enables the embryo's healthy development. During this dynamic period, major waves of epigenetic reprogramming, crucial for the normal fate of the embryo, take place. Over the past decade, concerns relating to the raised incidence of epigenetic anomalies and imprinting following ART have been raised by several authors. Epigenetic reprogramming is particularly susceptible to environmental conditions during the periconceptional period; therefore, unphysiological conditions, including ovarian stimulation, in vitro fertilization, embryo culture, cryopreservation of gametes and embryos, parental lifestyle, and underlying infertility, have the potential to contribute to epigenetic dysregulation independently or collectively. This review critically appraises the evidence relating to the association between ART and genetic and epigenetic modifications that may be transmitted to the offspring.
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