Analytical evaluation and bioclinical validation of new aldosterone and renin immunoassays

Article Peripheral Vascular Disease

Novel chemiluminescent immunoassay to measure plasma aldosterone and plasma active renin concentrations for the diagnosis of primary aldosteronism

Kyoko Teruyama et al.

Summary: Novel two-site sandwich chemiluminescent enzyme immunoassays (CLEIAs) were developed for simultaneous measurement of plasma aldosterone concentrations (PAC) and plasma active renin concentrations (ARC) with improved detection sensitivity and measurement accuracy. These CLEIAs can provide a clinically powerful alternative to conventional methods for hypertension screening in clinical practice.

JOURNAL OF HUMAN HYPERTENSION (2022)

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Article Peripheral Vascular Disease

Intraindividual Variability of Aldosterone Concentrations in Primary Aldosteronism Implications for Case Detection

Nicholas Yozamp et al.

Summary: Patients with primary aldosteronism exhibit high variability in aldosterone concentrations and aldosterone-to-renin ratios, with many screening values falling below conventionally accepted diagnostic thresholds. By recalibrating the definition of a positive screen to include more liberal thresholds for aldosterone and the aldosterone-to-renin ratio, the diagnostic yield for primary aldosteronism may be substantially increased.

HYPERTENSION (2021)

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Review Medical Laboratory Technology