Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex

Article Medicine, General & Internal

Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021

Matthew E. Oster et al.

Summary: Based on reports in the US, the risk of myocarditis after receiving mRNA-based COVID-19 vaccines was increased, especially among adolescent males and young men, particularly after the second dose. This risk should be considered in the context of the benefits of COVID-19 vaccination.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Biochemistry & Molecular Biology

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection

Martina Patone et al.

Summary: The study found that there is an increased risk of myocarditis associated with the first dose of ChAdOx1 and BNT162b2 vaccines, as well as the first and second doses of the mRNA-1273 vaccine in the 1-28 days post-vaccination period. Additionally, individuals with SARS-CoV-2 infection also face a greater risk of myocarditis, pericarditis, and cardiac arrhythmia.

NATURE MEDICINE (2022)

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Article Medicine, General & Internal

Myocarditis after Covid-19 Vaccination in a Large Health Care Organization

Guy Witberg et al.

Summary: Among 2.5 million patients who received the BNT162b2 mRNA vaccine in a large Israeli health care system, the incidence of myocarditis at 42 days was 2.13 cases per 100,000 persons, with the highest incidence (10.69 per 100,000 persons) among male patients between the ages of 16 and 29 years. Most cases of myocarditis were mild or moderate.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel

D. Mevorach et al.

Summary: The incidence of myocarditis increased after receiving the BNT162b2 vaccine in Israel, particularly after the second dose among young male recipients. The clinical presentation of myocarditis after vaccination was usually mild.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study

Anders Husby et al.

Summary: This study investigated the association between SARS-CoV-2 vaccination and myocarditis or myopericarditis, finding an increased risk of developing these conditions within 0-28 days post-vaccination, especially among individuals aged 12-39 and males.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Letter Medicine, General & Internal

Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older

Anthony Simone et al.

JAMA INTERNAL MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Myocarditis With COVID-19 mRNA Vaccines

Biykem Bozkurt et al.

Summary: Myocarditis is a rare complication of COVID-19 mRNA vaccines, predominantly affecting young adult and adolescent males, with most patients showing improvement in symptoms. Possible mechanisms include molecular mimicry between viral proteins and self-antigens, dysregulated immune pathways, immune response to mRNA, and dysregulated cytokine expression.

CIRCULATION (2021)

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Article Medicine, General & Internal

Surveillance for Adverse Events After COVID-19 mRNA Vaccination

Nicola P. Klein et al.

Summary: This study conducted interim analysis of safety surveillance data of mRNA COVID-19 vaccines and found that the incidence of selected serious outcomes within 1-21 days post-vaccination was not significantly higher compared with 22-42 days post-vaccination. Surveillance is ongoing despite wide confidence intervals for many outcomes.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal

Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting

Noam Barda et al.

Summary: The study found that after receiving the BNT162b2 vaccine, most adverse events were not associated with an increased risk, although there was a slight increase in the risk of myocarditis. On the other hand, infection with the Covid-19 virus significantly increased the risk of many serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems