Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-13C-Pyruvate-d3

The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is possible to perform metabolic imaging to reveal not only the exact location of a tumor, but also intratumoral areas of high metabolic activity. Herein, we demonstrate the feasibility of metabolic tumor imaging using signal-enhanced 1-C-13-pyruvate-d(3), which is rapidly enhanced via para-hydrogen, and thus, the signal is amplified by several orders of magnitudes in less than a minute. Using as a model, human melanoma xenografts injected with signal-enhanced 1-C-13-pyruvate-d3, we show that the conversion of pyruvate into lactate can be monitored along with its kinetics, which could pave the way for rapidly detecting and monitoring changes in tumor metabolism.

Automated summary

The metabolism of malignant cells can be imaged using signal-enhanced 1-C-13-pyruvate-d3, which is rapidly enhanced via para-hydrogen. This study demonstrates the feasibility of metabolic tumor imaging by monitoring the conversion of pyruvate into lactate and its kinetics, providing a potential method for rapidly detecting and monitoring changes in tumor metabolism.