4.7 Article

Neuronal differentiation pathways and compound-induced developmental neurotoxicity in the human neural progenitor cell test (hNPT) revealed by RNA-seq

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Legal

Integration of toxicodynamic and toxicokinetic new approach methods into a weight-of-evidence analysis for pesticide developmental neurotoxicity assessment: A case-study with DL- and L-glufosinate

Sarah Dobreniecki et al.

Summary: DL-glufosinate ammonium is a registered herbicide that has been studied for its developmental neurotoxicity (DNT). Offspring exposed to this herbicide showed changes in brain structure, decreased body weight, and increased motor activity. However, there is a lack of DNT studies for its enriched isomers, L-GLF acid and L-GLF ammonium. In vitro screening assays were conducted on these isomers, which showed no adverse effects on network formation and neurite outgrowth. The results suggest that conducting a guideline DNT study for the L-GLF isomers may not be necessary.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2022)

Review Biology

Toward a Better Testing Paradigm for Developmental Neurotoxicity: OECD Efforts and Regulatory Considerations

Magdalini Sachana et al.

Summary: Recognizing the current DNT testing paradigm is not suitable for assessing a large number of chemicals, scientific advances have been made in alternative methods to evaluate chemical interactions with the developing nervous system without using animals. The OECD provides internationally harmonised guidelines based on cellular models for testing and assessing chemicals for DNT. To address challenging endpoints like DNT, the OECD has been developing integrated approaches for testing and assessment, which rely on a combination of different data layers and mechanistic knowledge.

BIOLOGY-BASEL (2021)

Article Neurosciences

Evaluation of chemical compounds that inhibit neurite outgrowth using GFP-labeled iPSC-derived human neurons

Shuaizhang Li et al.

Summary: A reliable and efficient screening method was developed in this study to identify compounds that may adversely impact the nervous system, focusing on neurite outgrowth as a key process in neurodevelopment. Results showed that certain compounds selectively inhibited neurite outgrowth in cortical neurons or motor neurons, indicating potential neurotoxic effects in different cell types.

NEUROTOXICOLOGY (2021)

Review Reproductive Biology

Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps

Birgitte Lindeman et al.

Summary: Studies indicate that acrylamide (AA) exposure during gestation may have adverse effects on fetal growth and is associated with reduced head circumference in newborns. The impact of AA on the developing brain in humans has not yet been studied, highlighting the urgent need for further research on this topic.

REPRODUCTIVE TOXICOLOGY (2021)

Article Reproductive Biology

The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery of assays

Magdalini Sachana et al.

Summary: International collaboration has led to the consensus that a DNT testing battery based on key neurodevelopmental processes should be developed, with a focus on incorporating in vitro assays and leveraging Adverse Outcome Pathways for regulatory purposes.

REPRODUCTIVE TOXICOLOGY (2021)

Article Neurosciences

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Xiali Zhong et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

Is It Time to Start Transitioning From 2D to 3D Cell Culture?

Caleb Jensen et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Review Psychiatry

Antidepressant use in pregnancy: are we closer to consensus?

Daniel M. Campagne

ARCHIVES OF WOMENS MENTAL HEALTH (2019)

Review Neurosciences

Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling

Dario Pacitti et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Review Biochemistry & Molecular Biology

Synapse diversity and synaptome architecture in human genetic disorders

Seth G. N. Grant

HUMAN MOLECULAR GENETICS (2019)

Article Multidisciplinary Sciences

Gene expression across mammalian organ development

Margarida Cardoso-Moreira et al.

NATURE (2019)

Article Environmental Sciences

Effects of chlorpyrifos on cell death and cellular phenotypic specification of human neural stem cells

Laura Sandoval et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Review Toxicology

Today's Challenges to De-Risk and Predict Drug Safety in Human Mind-the-Gap

Richard J. Weaver et al.

TOXICOLOGICAL SCIENCES (2019)

Review Developmental Biology

Molecular specification of facial branchial motor neurons in vertebrates

Albert Y. Han et al.

DEVELOPMENTAL BIOLOGY (2018)

Article Public, Environmental & Occupational Health

Prenatal organophosphate insecticide exposure and infant sensory function

Monica K. Silver et al.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2018)

Review Toxicology

Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation

Ellen Fritsche et al.

TOXICOLOGICAL SCIENCES (2018)

Article Pharmacology & Pharmacy

Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment

Joshua A. Harrill et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods

Anna Bal-Price et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Medicine, Research & Experimental

Recommendation on Test Readiness Criteria for New Approach Methods in Toxicology: Exemplified for Developmental Neurotoxicity

Anna Bal-Price et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2018)

Article Medicine, Research & Experimental

Animal Testing and its Alternatives - the Most Important Omics is Economics

Lucy Meigs et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2018)

Article Biochemistry & Molecular Biology

CellProfiler 3.0: Next-generation image processing for biology

Claire McQuin et al.

PLOS BIOLOGY (2018)

Article Pharmacology & Pharmacy

Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro

Diana Lupu et al.

MOLECULAR PHARMACOLOGY (2018)

Review Developmental Biology

The Role of Apoptotic Signaling in Axon Guidance

Riley Kellermeyer et al.

JOURNAL OF DEVELOPMENTAL BIOLOGY (2018)

Article Clinical Neurology

Placental passage of antiepileptic drugs at delivery and neonatal outcomes

Anna M. Bank et al.

EPILEPSIA (2017)

Article Biochemical Research Methods

Salmon provides fast and bias-aware quantification of transcript expression

Rob Patro et al.

NATURE METHODS (2017)

Editorial Material Medicine, Research & Experimental

OECD/EFSA Workshop on Developmental Neurotoxicity (DNT): The Use of Non-Animal Test Methods for Regulatory Purposes

Ellen Fritsche et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2017)

Review Immunology

Transcription Factor C/eBP Homologous Protein in Health and Diseases

Yuan Yang et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Biochemical Research Methods

MultiQC: summarize analysis results for multiple tools and samples in a single report

Philip Ewels et al.

BIOINFORMATICS (2016)

Article Biochemistry & Molecular Biology

Methylmercury and brain development: A review of recent literature

Alessandra Antunes dos Santos et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2016)

Article Pharmacology & Pharmacy

Safety pharmacology investigations on the nervous system: An industry survey

Simon Authier et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2016)

Article Cell & Tissue Engineering

Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

Lisa Hoelting et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

Article Biochemical Research Methods

PathVisio 3: An Extendable Pathway Analysis Toolbox

Martina Kutmon et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

Article Rehabilitation

Antidepressants modulate glycine action in rat hippocampus

Hyun-Kyung Chang et al.

JOURNAL OF EXERCISE REHABILITATION (2015)

Article Chemistry, Medicinal

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

Tanja Waldmann et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2014)

Review Clinical Neurology

Neurobehavioural effects of developmental toxicity

Philippe Grandjean et al.

LANCET NEUROLOGY (2014)

Article Medicine, Research & Experimental

International STakeholder NETwork (ISTNET) for creating a developmental neurotoxicity testing (DNT) roadmap for regulatory purposes

Kevin Crofton

ALTEX-Alternatives to Animal Experimentation (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Review Pediatrics

Developmental neurotoxicity testing: A path forward

Kevin M. Crofton et al.

CONGENITAL ANOMALIES (2012)

Review Environmental Sciences

Molecular Mechanism of Acrylamide Neurotoxicity: Lessons Learned from Organic Chemistry

Richard M. LoPachin et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Neurosciences

Chlorpyrifos developmental neurotoxicity: Interaction with glucocorticoids in PC12 cells

Theodore A. Slotkin et al.

NEUROTOXICOLOGY AND TERATOLOGY (2012)

Review Biochemistry & Molecular Biology

Netrin-1 in the developing enteric nervous system and colorectal cancer

Suh Youn Ko et al.

TRENDS IN MOLECULAR MEDICINE (2012)

Article Psychiatry

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

Joachim Hallmayer et al.

ARCHIVES OF GENERAL PSYCHIATRY (2011)

Article Cell Biology

Signaling from Axon Guidance Receptors

Greg J. Bashaw et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Public, Environmental & Occupational Health

The Rise in Autism and the Role of Age at Diagnosis

Irva Hertz-Picciotto et al.

EPIDEMIOLOGY (2009)

Article Biochemical Research Methods

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Da Wei Huang et al.

NATURE PROTOCOLS (2009)

Review Medicine, General & Internal

Developmental neurotoxicity of industrial chemicals

P. Grandjean et al.

LANCET (2006)

Review Pharmacology & Pharmacy

Acrylamide axonopathy revisited

RM LoPachin et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)

Article Multidisciplinary Sciences

The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment

K Thiébault et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

Article Biochemistry & Molecular Biology

Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis

DANW Persaud-Sawin et al.

HUMAN MOLECULAR GENETICS (2002)

Article Toxicology

Dose-response modeling of continuous endpoints

W Slob

TOXICOLOGICAL SCIENCES (2002)