期刊
CHEMOSPHERE
卷 306, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2022.135603
关键词
Airpollution; Ozone; Chronickidneydisease; Urbanization; Long-term
资金
- National Natural Science Foundation of China [82003529, 72125009, 81771938, 81301296, 41590843]
- National Key R&D Program of the Ministry of Science and Technology of China [2019YFC2005000]
- Chinese Scientific and Technical Innovation Project 2030 [2018AAA0102100]
- University of Michigan Health System-Peking University Health Science Center Joint Institute for Translational and Clinical Research [BMU2018JI012, BMU2019JI005, 71017Y2027]
- CAMS Innovation Fund for Medical Sciences [2019-I2M-5-046]
- PKU-Baidu Fund [2019BD017, 2020BD004, 2020BD005, 2020BD032]
This study found that long-term exposure to O-3 may increase the risk of CKD in the general Chinese population. The impact was more significant in urban areas, among younger adults under 65 years, and individuals with higher socio-economic status.
The health hazards of ambient ozone (O-3) pollution are receiving increasing attention worldwide. However, the evidence on the association between O-3 and risks of chronic kidney disease (CKD) remains insufficient and inconsistent, particularly in developing countries where there is an absence of macroscopic investigations at a large population scale. Based on data from a representative nationwide cross-sectional CKD survey in 13 Chinese provinces and a high resolution O-3 air pollution inversion dataset, generalized linear models were used to evaluate the associations of O-3 concentration with prevalence of CKD. The results of this study suggested that long-term O-3 exposure was positively associated with the risk of CKD. A 10 mu g/m(3) increment in O-3 concentration was associated with an increased odds of CKD prevalence [OR = 1.11 (95% CI: 1.03, 1.21)] among all the 47,086 participants. Stronger associations were found in urban regions, younger adults < 65 years, and people with higher socio-economic status (income and education level). A 10 mu g/m(3 )increment in O-3 concentration was associated with a higher increased odds of CKD prevalence in urban regions [OR = 1.31 (95% CI: 1.16, 1.47)] compared to rural regions [OR = 0.95 (95% CI: 0.84, 1.08), P for subgroup difference < 0.001]. A stronger association of O3 concentration with CKD prevalence was found among younger people aged < 65 years [OR = 1.21 (95% CI: 1.10, 1.33)] compared to those aged >= 65 years [OR = 0.92 (95% CI: 0.79, 1.07), P for subgroup difference = 0.003]. Our study demonstrated that long-term O-3 exposure may increase risk of CKD in the general Chinese population, and the findings stressed the importance of persistent efforts in air pollution prevention and control.
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