☆ 4.6 Review

Production and Application of Biomaterials Based on Polyvinyl alcohol (PVA) as Wound Dressing

CHEMISTRY-AN ASIAN JOURNAL (2022)

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Freeze/thawed polyvinyl alcohol hydrogels: Present, past and future

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Summary: A comprehensive review of polyvinyl alcohol (PVA) hydrogels prepared by the freezing/thawing (F-T) process is presented. We discuss their preparation, gelation mechanisms, handling of physical/mechanical properties, physicochemical characteristics, and various applications. PVA hydrogels have the advantages of easy customization and biocompatibility, making them suitable for diverse applications in the medical field and sensor technology.

EUROPEAN POLYMER JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Silk fibroin/polycaprolactone-polyvinyl alcohol directional moisture transport composite film loaded with antibacterial drug-loading microspheres for wound dressing materials

Ting-Ting Li et al.

Summary: This paper proposes a multifunctional medical dressing that can prevent wound infection and inflammatory reactions and accelerate wound healing. By constructing a composite nanofiber membrane and preparing mesoporous silica nanoparticles with high adsorption properties, drug loading and release are achieved, and good antibacterial effect and biocompatibility are demonstrated. This study stimulates the use of wound healing biomaterials in clinical medicine.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Pharmacology & Pharmacy

Calendula flower extract loaded PVA hydrogel sheet for wound management: Optimization, characterization and in-vivo study

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Summary: The aim of this study was to prepare a hydrogel sheet containing calendula flower extract and evaluate its stability, safety, and wound healing activity in experimental rats. The results showed that the CFE-loaded hydrogel sheet was stable, safe, and promoted wound healing activity.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Polymer Science

New Insights of Scaffolds Based on Hydrogels in Tissue Engineering

Denisa-Maria Radulescu et al.

Summary: In recent years, the development and characterization of biomaterials for regenerative medicine and controlled release have posed significant challenges. Hydrogels are considered optimal applications in the biomedical field, particularly in tissue engineering. However, their delicate nature and low mechanical strength limit their use. Therefore, developing stronger and more stable hydrogels with increased biocompatibility is essential. Natural and synthetic polymers both have limitations, but the development of hydrogels based on mixtures of these materials can optimize their properties. Incorporating different nanoparticles can improve stability and yield various biological effects. Essential oils and drug molecules can facilitate desired biological effects and even produce a synergistic effect. The main purpose of this study is to identify the key properties required to develop sustainable polymeric scaffolds for tissue engineering without adverse environmental effects.

POLYMERS (2022)

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Article Critical Care Medicine

Characterization of a novel semi-interpenetrating hydrogel network fabricated by polyethylene glycol diacrylate/polyvinyl alcohol/tragacanth gum as a wound dressing

Forough Hemmatgir et al.

Summary: In this research, a novel semi-interpenetrating hydrogel network with adaptable characteristics was fabricated for wound healing purposes. The chemical structure and surface morphology were examined. The hydrogels' swelling ratio, mechanical characteristics, water vapor transmission rate, gel fraction, degradability, cytocompatibility, and antibacterial activity were assessed.

BURNS (2022)

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Article Engineering, Biomedical

Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing

Yutong Yang et al.

Summary: This study developed a photo-crosslinked multifunctional antibacterial adhesive hemostatic hydrogel dressing that can disinfect drug-resistant bacteria and promote wound healing. Through various tests, it showed good hemostatic and antibacterial properties, and proved to be more effective than current commercially available dressings in treating infected wounds.

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Review Chemistry, Applied

Chondroitin Sulfate: Emerging biomaterial for biopharmaceutical purpose and tissue engineering

Reena Sharma et al.

Summary: Chondroitin Sulfate (CS) is a versatile polysaccharide with various activities such as anti-inflammatory, antioxidant, antitumor, and anticoagulant. It is biodegradable, biocompatible, and capable of targeted drug delivery and site-specific drug release. CS-based nanocarriers and stimuli-sensitive delivery systems have promising applications in drug delivery, tissue engineering, wound healing, and tumor targeting.

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Article Chemistry, Applied

Bio-orthogonally crosslinked catechol-chitosan hydrogel for effective hemostasis and wound healing

Hang Li et al.

Summary: CS-PEG-HA hydrogel exhibits outstanding adhesion and hemostasis properties, enabling rapid repair of liver bleeding and accelerated healing of skin wounds.

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Review Chemistry, Multidisciplinary

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Jasmin Omar et al.

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CHEMISTRY-AN ASIAN JOURNAL (2022)

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Article Chemistry, Physical

Double crosslinked polyvinyl alcohol/gelatin/silver sulfadiazine sponges with excellent antibacterial performance

Sirui He et al.

Summary: In this study, a double crosslinking strategy was used to fabricate novel PGA sponges. The morphology and chemical composition of the sponges were characterized, and their antibacterial activity was evaluated. The results showed that the PGA sponges exhibited excellent antibacterial performance due to the release of silver sulfadiazine, and the release of sulfadiazine was diffusion controlled. These prepared PGA sponges showed improved mechanical properties and excellent antibacterial effects.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2022)

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Article Chemistry, Inorganic & Nuclear

An Effective Wound Healing Material Based on Gold Incorporation into a Heparin-Polyvinyl Alcohol Nanocomposite: Enhanced In Vitro and In Vivo Care of Perioperative Period

Kunxian Zhang et al.

Summary: The study fabricated a highly porous H-PVA@Au nanocomposite dressing with good antimicrobial activity and biocompatibility, suitable for treating burn injuries.

JOURNAL OF CLUSTER SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Multilayered 3-D nanofibrous scaffold with chondroitin sulfate sustained release as dermal substitute

Amin Sadeghi et al.

Summary: Electrospun nanofibers for skin tissue engineering face challenges due to low thickness and limited cell penetration. Researchers have developed a multi-layered nanofibrous scaffold through electrospinning, which has improved mechanical performance, sustained drug release, and enhanced cell penetration.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Dual Spinneret Electrospun Polyurethane/PVA-Gelatin Nanofibrous Scaffolds Containing Cinnamon Essential Oil and Nanoceria for Chronic Diabetic Wound Healing: Preparation, Physicochemical Characterization and In-Vitro Evaluation

Mohamed Ahmed Mohamady Hussein et al.

Summary: In this study, a dual spinneret electrospinning technique was used to produce a novel polyurethane and polyvinyl alcohol-gelatin nanofibrous scaffold. By incorporating cinnamon essential oil and nanoceria, the mechanical and thermal stability of the scaffold were improved. Cytotoxicity evaluation showed that the presence of cinnamon essential oil and nanoceria in the scaffold enhanced cell population and inhibited the growth rate of Staphylococcus aureus.

MOLECULES (2022)

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Article Dermatology

A collagen-based bi-layered composite dressing for accelerated wound healing

Leilei Sun et al.

Summary: The aim of this study was to develop collagen-based composite dressings for wound healing and investigate their mechanisms. The results showed that the non-crosslinked collagen-based bi-layered composite dressing stimulated wound healing, reduced inflammation, upregulated growth factors, and promoted collagen synthesis and fibroblast proliferation. This study provided theoretical support for the potential application of collagen-based composite dressings in wound healing.

JOURNAL OF TISSUE VIABILITY (2022)

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Article Multidisciplinary Sciences

Novel antibacterial hydrogels based on gelatin/polyvinyl-alcohol and graphene oxide/silver nanoconjugates: formulation, characterization, and preliminary biocompatibility evaluation

Jorge Luis Patarroyo et al.

Summary: The study developed a novel topical hydrogel treatment containing graphene oxide-silver nanoparticles nanoconjugate, which effectively inhibits microbial growth and exhibits good biocompatibility. The physical-chemical, stability, and biological evaluations showed excellent performance in antimicrobial, wound healing, and tissue engineering applications.

HELIYON (2022)

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Article Materials Science, Biomaterials

Alginate/PVA-based hydrogel matrices with Echinacea purpurea extract as a new approach to dermal wound healing

Katarzyna Bialik-Was et al.

Summary: Sodium alginate/poly(vinyl alcohol) hydrogels containing Echinacea purpurea extract with antioxidant activity were developed, and the swelling ability of the hydrogels increased with the extract contents. The presence of extract influenced the morphology of the hydrogels, with higher extract percentages leading to more porous structures. Additionally, degradation tests showed a gradual increase in conductivity over time, indicating the expected rate of material degradation.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2021)

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Aquatic polymer-based edible films of fish gelatin crosslinked with alginate dialdehyde having enhanced physicochemical properties

Jinseok Park et al.

Summary: In this study, a water-stable and mechanically robust fish-derived gelatin (FG) film was successfully prepared using alginate dialdehyde (ADA) as a crosslinking agent. The mechanical strength and Young's modulus of the FG/ADA composite film significantly increased with an increase in the content of ADA, with FG/ADA10 film showing stability under wet conditions. The crosslinking process with ADA not only improved the mechanical properties but also enhanced the antioxidative capacity of the FG/ADA edible film, suggesting potential practical applications in the edible film-based packaging industry.

CARBOHYDRATE POLYMERS (2021)

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Article Materials Science, Biomaterials

Hyaluronic Acid/Oxidized K-Carrageenan Electrospun Nanofibers Synthesis and Antibacterial Properties

A. Abou-Okeil et al.

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BIONANOSCIENCE (2021)

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Article Materials Science, Biomaterials

Advanced SA/PVA-based hydrogel matrices with prolonged release of Aloe vera as promising wound dressings

Katarzyna Bialik-Was et al.

Summary: The study demonstrated that SA/PVA hydrogel films containing Aloe vera exhibited higher thermal stability and improved active substance release properties. Additionally, the Aloe vera hydrogel films showed positive effects on cell adhesion and proliferation.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Polymer Science

Electrospinning of polyvinyl alcohol/chitosan/hyaluronic acid nanofiber containing growth hormone and its release investigations

Hossein Hosseini et al.

Summary: Nanofibers prepared via electrospinning method are a new treatment method for difficult-to-heal wounds, providing hydrophilic and non-toxic characteristics with sustained release of therapeutic proteins.

POLYMERS FOR ADVANCED TECHNOLOGIES (2021)

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Article Pharmacology & Pharmacy

Development of clindamycin-loaded alginate/pectin/hyaluronic acid composite hydrogel film for the treatment of MRSA-infected wounds

Nurhasni Hasan et al.

Summary: The study developed clindamycin (Cly)-loaded composite biopolymer films for the treatment of MRSA-infected wounds, showing promising physical properties, in vitro drug release, in vitro antibacterial effects, and in vivo wound healing activity in a mouse model of MRSA-infected wounds.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2021)

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Article Dermatology

Moist Wound Healing with Commonly Available Dressings

Kristo Nuutila et al.

Summary: A moist wound environment facilitates faster and higher quality healing by supporting autolytic debridement, reducing pain, activating collagen synthesis, and promoting cell migration. Utilizing various types of moist wound dressings and implementing smart dressings with integrated microsensors for real-time monitoring and treatment are key trends for the future.

ADVANCES IN WOUND CARE (2021)

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Article Chemistry, Multidisciplinary

Engineered Bio-inspired Multifunctional Peptide- and Protein-based Therapeutic Biomolecules for Better Wound Care

Paramita Gayen et al.

Summary: Developing non-immunogenic therapeutic biomolecules for facilitating blood clotting followed by wound healing via therapeutic angiogenesis is a formidable challenge. Advancements in stabilized growth-factor-based proangiogenic therapy offer effective possibilities for the treatment of ischemic pathology. Nature-inspired biocompatible stabilized peptide- and protein-based molecular medicines are being explored to address traumatic coagulopathy and impaired wound healing.

CHEMISTRY-AN ASIAN JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Antibiotic-free combinational hyaluronic acid blend nanofibers for wound healing enhancement

Mohamed R. El-Aassar et al.

Summary: The study innovatively functionalized nanofibers with a combination of new ZnO NPs and cinnamon essential oil, showing great potential for wound healing. The combinational approach of metal NPs/essential oil functionalization of nanofibers is promising as an emerging antibiotic-free method for effective and safer wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Engineering, Multidisciplinary

Novel composite double-layered dressing with improved mechanical properties and wound recovery for thermosensitive drug, Lactobacillus brevis

Heesun Yu et al.

Summary: This study aimed to develop a novel composite double-layered dressing (CDD) for an effective treatment of infected wounds and improved wound recovery. The LB-loaded hydrogel top layer was prepared using the freeze-thawing method, while the external layer of the dressing was produced using the high-temperature melting method, resulting in excellent mechanical properties and drug release. The developed LB-loaded CDD showed enhanced wound healing efficacy in infected wounds, making it a potential thermosensitive drug carrier for improving wound recovery.

COMPOSITES PART B-ENGINEERING (2021)

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Article Nanoscience & Nanotechnology

Antimicrobial Double-Layer Wound Dressing Based on Chitosan/Polyvinyl Alcohol/Copper: In vitro and in vivo Assessment

Ensieh Ghasemian Lemraski et al.

Summary: This study successfully prepared chitosan/polyvinyl alcohol/copper nanofibers by incorporating copper nanoparticles into nanofiber dressings, demonstrating their effective antimicrobial properties. The prepared hydrogel formulations were shown to provide proper care for open wounds in the early stages of wound healing and prevent the occurrence of prolonged open wounds.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Pharmacology & Pharmacy

Core-shell chitosan/PVA-based nanofibrous scaffolds loaded with Satureja mutica or Oliveria decumbens essential oils as enhanced antimicrobial wound dressing

Sajjad Barzegar et al.

Summary: The study developed core-shell nanofibrous scaffolds based on chitosan with antioxidant and antimicrobial properties, encapsulating Satureja mutica or Oliveria decumbens essential oils. The scaffolds exhibited uniform structure, good mechanical properties, enhanced antioxidant activity, and broadened antimicrobial activity when loaded with essential oils. These results suggest that the CS/PVA/EO-PVP/MD nanofibrous scaffolds are promising candidates for wound dressing applications.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Polyvinyl alcohol/chitosan wound dressings loaded with antiseptics

E. Massarelli et al.

Summary: A new PVA/Ch based wound dressing was developed, which showed protection, hydration, and controlled release of antiseptics. The dressings exhibited antibacterial activity against S. aureus and S. epidermidis, with the ones loaded with PHMB showing better cytotoxicity and irritability properties. The application of this dressing in wound treatment in a dog led to faster recovery compared to conventional treatment, suggesting its potential as an alternative in wound care.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

Mina Keshvardoostchokami et al.

Summary: Research on various types of polymer nanofibers as artificial extracellular matrices has shown controllable physiochemical properties, enabling the engineering of microenvironments to support cell function through functionalization. The nanofibrous scaffolds were categorized into five main groups, and their role in supporting cellular function was discussed.

NANOMATERIALS (2021)

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Article Pharmacology & Pharmacy

Novel ezetimibe-loaded fibrous microparticles for enhanced solubility and oral bioavailability by electrospray technique

Wookyung Kim et al.

Summary: This study developed a novel electrospray-based fibrous microparticle loaded with ezetimibe, which significantly improved its water solubility and dissolution. The optimized microparticles exhibited higher solubility and dissolution rates compared to ezetimibe powder, and showed enhanced bioavailability in vivo, providing a new approach for enhancing the poorly water-soluble drug ezetimibe.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Bio-functional hydrogel membranes loaded with chitosan nanoparticles for accelerated wound healing

Maryam Shafique et al.

Summary: This study developed a novel wound dressing based on hydrogel membranes loaded with cefepime nanoparticles, which showed promising potential for accelerating wound healing process. The in vitro analysis indicated that the developed membrane has ideal water vapor transmission rate and oxygen permeability, along with sustained drug release and high zone of inhibition against various bacteria.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

Polyvinyl alcohol based-drug delivery systems for cancer treatment

Gabriela Rivera-Hernandez et al.

Summary: Polyvinyl alcohol (PVA) is a biodegradable synthetic polymer with high biocompatibility and non-toxicity, widely used in biomedical and pharmaceutical applications. Utilizing PVA to prepare hydrogels, microparticles, or nanoparticles for cancer treatment shows promising results in improving drug solubility, targeted drug delivery, and reducing toxicity and side effects. The combination of PVA with copolymers has emerged as a viable strategy for building novel functional composites for drug delivery systems in cancer treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Materials Science, Biomaterials

Fabrication of antibacterial sericin based hydrogel as an injectable and mouldable wound dressing

Gang Tao et al.

Summary: A novel hydrogel wound dressing was developed by functionalizing sodium alginate with silk sericin, which showed effective antibacterial activity and high cytocompatibility. In animal experiments, the hydrogel exhibited a high wound contraction ratio, indicating its potential for wound healing and tissue engineering.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Multidisciplinary Sciences

Epidermal and fibroblast growth factors incorporated polyvinyl alcohol electrospun nanofibers as biological dressing scaffold

Amnah Asiri et al.

Summary: Different structures of PVA nanofiber wound dressing scaffolds were prepared and their biological activities were verified in vitro and in vivo studies. Changes in morphological features of nanofibers after growth factor incorporation were observed, promoting cell proliferation and growth. In animal experiments, mix and multilayer scaffolds had a better promotion effect on wound healing.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Physical

Facile preparation of agar/polyvinyl alcohol-based triple-network composite hydrogels with excellent mechanical performances

Ran Wang et al.

Summary: Triple-network hydrogels were successfully prepared using freezing method and free radical polymerization to create physical and chemical cross-linked structures, enhancing the mechanical properties and stability of the material. The composite hydrogel showed rapid self-recovery after consecutive and discontinuous compressions, providing a new idea for the preparation of multifunctional hydrogels with good thermal stability, mechanical properties, and self-recovery capability.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

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Article Materials Science, Multidisciplinary

Novel fibrin functionalized multilayered electrospun nanofiber membrane for burn wound treatment

Md Eman Talukder et al.

Summary: A novel hybrid multilayered electrospun nanocomposite membrane (MENM) was developed for activated wound dressing applications, showing excellent antibacterial activity and high water absorbency, which could potentially be used as wound dressing materials in the future.

JOURNAL OF MATERIALS SCIENCE (2021)

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Review Biology

Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Jingjing Su et al.

Summary: Wounds are a leading cause of death worldwide, and the development of multifunctional hydrogel wound dressings is crucial for effective treatment of chronic wounds. The unique properties of hydrogels make them an ideal candidate for wound care, overcoming the limitations of traditional dressings. However, there are still challenges in the development and widespread use of hydrogel dressings.

LIFE-BASEL (2021)

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Article Materials Science, Multidisciplinary

Fabrication of Cellulosic Nonwoven Material Coated with Polyvinyl Alcohol and Zinc Oxide/Mesoporous Silica Nanoparticles for Wound Dressing Purposes with Cephalexin Delivery

Mozhgan Nikdel et al.

Summary: The study explored the fabrication of wound dressings with antibacterial properties using non-woven fabric treated with polyvinyl alcohol hydrogel including zinc oxide nanoparticles and mesoporous silica nanoparticles. The addition of antibiotic cephalexin to the composite coating aided in mitigating bacterial infection. The nanocomposite demonstrated significant water uptake capacity, increased swelling ratio with the incorporation of nanoparticles, and showed excellent antibacterial properties against common pathogenic bacteria.

ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY (2021)

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Article Chemistry, Medicinal

Wound Healing Promotion by Hyaluronic Acid: Effect of Molecular Weight on Gene Expression and In Vivo Wound Closure

Yayoi Kawano et al.

Summary: The study found that the molecular weight and concentration of hyaluronic acid can enhance the proliferation and migration ability of epidermal cells, especially high molecular weight hyaluronic acid has a significant impact on gene expression in keratinocytes, which may help improve the re-epithelialization process of chronic wounds.

PHARMACEUTICALS (2021)

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Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

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Article Chemistry, Applied

Preparation and properties of polyvinyl alcohol/N-succinyl chitosan/lincomycin composite antibacterial hydrogels for wound dressing

Xiaoyan Qing et al.

Summary: The PVA/NSCS/lincomycin hydrogel showed high water absorption capacity, antibacterial activity, and biocompatibility, making it a promising candidate for wound dressing applications.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Poly(vinyl alcohol)/(hyaluronic acid-g-kappa-carrageenan) hydrogel as antibiotic-releasing wound dressing

Zehra Ozbas et al.

Summary: The study investigated the potential of ampicillin-loaded hydrogels for wound dressing applications, specifically focusing on a novel PVA/(HA-g-(K)-Carr) hydrogel. This hydrogel demonstrated superior swelling, ampicillin release, antimicrobial properties, and non-toxicity, making it a promising candidate for wound care.

CHEMICAL PAPERS (2021)

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Article Biochemistry & Molecular Biology

Propolis loaded and genipin-crosslinked PVA/chitosan membranes; characterization properties and cytocompatibility/genotoxicity response for wound dressing applications

Seda Ceylan

Summary: Loading of propolis using genipin as a crosslinking agent and fabrication of PVA/Chitosan-Propolis membrane scaffolds for wound dressing applications were studied. Propolis significantly affected the properties of the membrane, with the propolis-incorporated membrane showing high cell proliferation rates.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Recent advances in PVA-polysaccharide based hydrogels and electrospun nanofibers in biomedical applications: A review

Elbadawy A. Kamoun et al.

Summary: This study extensively discussed the modern perspectives of synthesized/developed electrospun nanofibrous hydrogel membranes based on popular carbohydrate polymers blend PVA, which have been widely used in versatile biomedical applications, particularly wound dressings, and compared them in detail with traditional fabricated membranes based films. The clinically relevant advantages of electrospun nanofibrous membranes were highlighted in terms of their biocompatibility, easy fabrication, and functionalization for different biomedical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Infectious Diseases

A New Dermal Substitute Containing Polyvinyl Alcohol with Silver Nanoparticles and Collagen with Hyaluronic Acid: In Vitro and In Vivo Approaches

Dario Mendes Junior et al.

Summary: The combination of PVA and collagen-hyaluronic acid (col-HA) membrane in a bilaminar device showed potential therapeutic effects for skin repair by preventing infections and dehydration, reducing typical wound inflammatory responses, and promoting cellular healing responses, suggesting further clinical trials are warranted.

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Review Engineering, Biomedical

Growth factor delivery using extracellular matrix-mimicking substrates for musculoskeletal tissue engineering and repair

Robert C. H. Gresham et al.

Summary: Therapeutic approaches for musculoskeletal tissue regeneration commonly use growth factors to influence nearby cells for migration, proliferation, or differentiation. However, challenges in clinical translation include poor control and high dosages leading to side effects. The extracellular matrix plays a key role in regulating growth factor presentation and retention, impacting tissue regeneration.

BIOACTIVE MATERIALS (2021)

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Review Engineering, Biomedical

Poly (ε-caprolactone)-based electrospun nano-featured substrate for tissue engineering applications: a review

B. Sowmya et al.

Summary: One major objective of tissue engineering is to restore the normal functioning of damaged tissues, with scaffolds playing a crucial role in providing support and substrate for tissue regeneration. Biopolymers like PCL are promising materials for scaffold fabrication, with electrospinning being a popular technique for their production.

PROGRESS IN BIOMATERIALS (2021)

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Review Pharmacology & Pharmacy

Microneedle for transdermal drug delivery: current trends and fabrication

Jae Hwan Jung et al.

Summary: Transdermal drug delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. Microneedles are a painless, less invasive, and easy to self-administer transdermal drug delivery system with high drug bioavailability. With advancements in formulation technologies, the drug-loading capability of microneedles can be improved.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2021)

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Composite hydrogels based on gelatin, chitosan and polyvinyl alcohol to biomedical applications: a review

Rogelio Rodriguez-Rodriguez et al.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2020)

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A novel multilayer hydrogel wound dressing for antibiotic release

Emel Tamahkar et al.

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Electrospun PVA nanoscaffolds associated with propolis nanoparticles with wound healing activity

Thais B. Alberti et al.

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Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review

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EUROPEAN POLYMER JOURNAL (2020)

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Development of the PVA/CS nanofibers containing silk protein sericin as a wound dressing: In vitro and in vivo assessment

Hamid Reza Bakhsheshi-Rad et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Development of a polyvinyl alcohol/sodium alginate hydrogel-based scaffold incorporating bFGF-encapsulated microspheres for accelerated wound healing

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SCIENTIFIC REPORTS (2020)

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Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing

Sha Liu et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Materials Science, Biomaterials

Fabrication of biocompatible antibacterial nanowafers based on HNT/PVA nanocomposites loaded with minocycline for burn wound dressing

Alireza Mohebali et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Materials Science, Biomaterials

Encapsulation of green tea polyphenol nanospheres in PVA/alginate hydrogel for promoting wound healing of diabetic rats by regulating PI3K/AKT pathway

Guanyu Chen et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Polymer Science

Chitosan/PVA hydrogels incorporated with green synthesized cerium oxide nanoparticles for wound healing applications

Katayoon Kalantari et al.

EUROPEAN POLYMER JOURNAL (2020)

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