期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 17, 期 20, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202200762
关键词
electrochemistry; indoles; intramolecular cyclization; peptide labeling; selenium catalyst
资金
- National Natural Science Foundation of China [81872759, 22177039, 21901052]
- Guangdong Basic and Applied Basic Research Foundation [2020A1515010722]
- Guangzhou Science and Technology Project [202102020979]
- Pearl River talent program of Guangdong Province (2019)
A novel selenium-electrocatalytic intramolecular cyclization has been developed for the synthesis of functionalized indoles and azaindoles. This sustainable method enables broad substrate scope and synthesis of highly functional indoles under mild conditions, using a recyclable selenium catalyst.
A novel selenium-electrocatalytic intramolecular cyclization of 2-vinylanilides for synthesis of functionalized indoles and azaindoles has been developed. In contrast to the previous synthetic methods, this sustainable protocol enabled unparalleled broad substrates scope for viable indoles with highly functional and sensitive groups by employing recyclable selenium catalyst, under mild, metal- and external-oxidant-free conditions. The approach can be used to the late-stage modification of complex bioactive molecular system, thereby setting the stage for versatile syntheses of decorated indoles with peptide labeling. A plausible catalytic pathway was proposed.
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