Iron Catalysis: A New Horizon Towards Organoboron-mediated C-C Cross-coupling

Transition metal-catalyzed cross-couplings have had a profound impact on chemical synthesis. Among the various transition metals, iron has drawn huge attention due to its cost effectiveness, range of stable oxidation states, Lewis acidic property and releatively less toxicity. Iron complexes have exhibited an efficient catalytic activity towards the cross-coupling reaction using organomagnesium, organolithium and organozinc reagent. Organoboron compounds are also engaged as a coupling partner for Fe catalysed C-C bond forming reactions. Over the last two decades' various iron catalysed C-C bond forming reactions have been developed. This review will summarize the chronological development in this research area along with challenges appearing especially in the past decade.

Automated summary

Transition metal-catalyzed cross-coupling reactions have had a significant impact on chemical synthesis. Among these, iron catalysis has attracted attention due to its cost effectiveness, stable oxidation states, Lewis acidity, and relatively low toxicity. This review summarizes the development of iron-catalyzed C-C bond forming reactions over the past two decades, highlighting the challenges encountered in the past decade.