期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 28, 期 65, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202202226
关键词
antifungal polymer; cell-penetrating peptides; drug resistance; host defense peptides; peptidomimetics
资金
- National Natural Science Foundation of China [22075078, 21861162010]
- Free exploring basic research project at Shenzhen Research Institute of ECUST [2021Szvup042]
- Program of Shanghai Academic/Technology Research Leader [20XD1421400]
- China National Postdoctoral Program for Innovative Talents [BX2021102, BX20220108]
- China Postdoctoral Science Foundation [2021M701198, 2022M710050]
Host defense peptides and cell-penetrating peptides are important strategies in designing synthetic antifungal agents, but the potential of cell-penetrating peptides has been overlooked in this field. This article describes the structural design of synthetic antifungal polymers and highlights the effectiveness of the cell-penetrating peptide-inspired strategy, as well as presents an outlook for future research.
The high-mortality invasive fungal infections seriously threaten the lives of immunocompromised people. Host defense peptides and cell-penetrating peptides are representative membrane-active peptides with different functions. Among them, host defense peptides mimicking is a valid strategy in the design of synthetic antifungal agents. Despite the brilliance in the field of intracellular delivery, the potential of cell-penetrating peptides and their mimics for designing antifungal agents has been overlooked. In this concept article, we describe the structural design of synthetic antifungal polymers as mimics of host defense peptides, and highlight the effectiveness and potential of cell-penetrating peptide-inspired strategy in designing potent and selective antifungal polymeric agents. In addition, an outlook for further expanding the design horizons of antifungal polymers is also presented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据