PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of F-18-labelled [Pd2L4](4+) metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

Automated summary

In this study, the synthesis of F-18-labelled[Pd2L4](4+) metallacages was reported for the advancement of self-assembled metallosupramolecular architectures as new generation theranostic agents. Various spectroscopic and bio-analytical methods supported the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, either alone or encapsulating cisplatin, were studied using PET/CT imaging in healthy mice in vivo, in combination with ICP-MS ex vivo.