期刊
CHEMISTRY & BIODIVERSITY
卷 19, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202200870
关键词
Abelia macrotera; terpenoids; phenylpropanoids; X-ray single-crystal diffraction; anti-inflammatory activity
资金
- National Natural Science Foundation of China (NSFC) [82141216]
- Chunhui Program-Cooperative Research Project of the Ministry of Education, Liaoning Province Natural Science Foundation [2022-MS-241, 2020-MZLH-31]
- Shenyang Young and Middle-aged Innovative Talents Support Program [RC210446]
- Joint National Local Engineering Research Center of Fujian
- Joint National Local Engineering Research Center of Fujian and Taiwan Chinese Medicine Molecular Biotechnology, Fujian Key Laboratory of Chinese Materia Medica, Fujian University Key Laboratory for Research and Development of TCM Resources, at Fujian Unive
A new triterpenoid with anti-inflammatory activity was isolated from Abelia macrotera, along with known terpenoids and phenylpropanoids.
A new triterpenoid, 3 beta-hydroxyurs-12-en-28,20 beta-olide (1), as well as thirteen known terpenoids (2-14) and three known phenylpropanoids (15-17), were isolated from the twigs and leaves of Abelia macrotera. Compounds 2, 5-17 were isolated for the first time from the Abelia genus. The structure of compound 1 was determined using the characteristic spectral data (HR-ESI-MS, UV, 1D and 2D-NMR, and X-ray single-crystal diffraction. Furthermore, the inhibitory effects of all compounds on NO production in LPS-induced RAW 264.7 cells were tested, and compound 15 showed obvious inhibitory effect, with IC50 values of 23.77 +/- 1.61 mu M. Through target screening and molecular docking technology, it can be speculated that compound 15 may play an anti-inflammatory role by combining with Cathepsin G & Chymase and HPG D.
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