期刊
CHEMICAL PAPERS
卷 77, 期 1, 页码 89-99出版社
SPRINGER INT PUBL AG
DOI: 10.1007/s11696-022-02452-1
关键词
Celecoxib; Pyrazole; Ga-MCM-41-SO3H; Solid acid
The application of a new efficient heterogeneous catalyst Ga-MCM-41-SO3H for the synthesis of celecoxib and pyrazole derivatives under room temperature is reported. The catalyst exhibited high yield and stability, and could be reused multiple times.
The application of Ga-MCM-41-SO3H as a new efficient heterogeneous catalyst for the synthesis of celecoxib and pyrazole derivatives under room temperature is reported. The mesoporous material Ga-MCM-41 was first prepared and then functionalized with the sulfonic acid group by the post-synthetic modification to obtain the final solid acid catalyst. The successful grafting of the -SO3H group onto the Ga-MCM-41 mesoporous walls was asserted by X-ray diffraction, scanning electron microscopy equipped with energy dispersive spectroscopy (SEM/EDS), and acid-base titration. The catalytic application of Ga-MCM-41-SO3H in the synthesis of celecoxib and pyrazole derivatives has resulted in a high yield (up to 95%) under mild conditions. Notably, the Ga-MCM-41-SO3H catalyst was stable and was able to reuse at least five times without losing significant catalytic activity. [GRAPHICS] .
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