期刊
CHEMICAL ENGINEERING JOURNAL
卷 446, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2022.136932
关键词
Graphitic carbon nitride quantum dots; One-pot synthesis; Targeted imaging; Biocompatibility; Fluorescence
资金
- Scientific Research Funds of Hua-qiao University [605-50Y18030]
- Quanzhou City Scien-ce&Technology Program of China [2018C080R]
- Natural Science Foundation of Fujian Province [2019J01079]
- Subsidized Project for Postgraduates?
- Innovative Fund in Scientific Research of Huaqiao University
This study presents a universal strategy for preparing targeting agent functionalized CNQDs using folate as an example. The FA-CNQDs exhibit bright fluorescence, favorable colloidal stability, and good cytocompatibility and in vivo biocompatibility. The remarkable performance of FA-CNQDs in targeted imaging is demonstrated.
Graphitic carbon nitride quantum dots (CNQDs) have been widely used in bioimaging due to the unique structure and optical properties, but only a few works demonstrate targeted imaging. Herein, we report a universal one-pot strategy for preparation of targeting agent functionalized CNQDs by taking folate (FA) as an example through hot-fluid annealing of triazine tectons and derived FA. The FA-CNQDs with size of 3 ~ 8 nm exhibit bright fluorescence, favorable colloidal stability, and well cytocompatibility and in vivo biocompatibility. The remarkable performance of FA-CNQDs in targeted imaging is demonstrated by incubation study with folate receptor overexpressed cancer cells and the cell derived multicellular spheroids. This convenient strategy would open a new avenue for synthesis of various functionalized CNQDs.
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