期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 101, 期 5, 页码 1151-1161出版社
WILEY
DOI: 10.1111/cbdd.14118
关键词
malignancy; non-coding RNAs; PI3K/AKT/mTOR; SIRT1; Snail-EMT; SNHGs; Wnt/beta-catenin
LncRNAs and miRNAs, two crucial non-coding RNAs, play significant roles in cancer progression or prevention. Dysregulation of lncRNAs, particularly lncRNA SNHG7, can interact with miRNAs and impact various signaling pathways, thus contributing to cancer development.
LncRNAs and miRNAs are the two most important non-coding RNAs, which have been identified to be associated with cancer progression or prevention. The dysregulation of lncRNAs conducts tumorigenesis and metastasis in different ways. One of the mechanisms is that lncRNAs interact with miRNAs to regulate distinct cellular and genomic processes and cancer progression. LncRNA SNHG7 as an oncogene sponges miRNAs and develops lncRNA-miRNA-mRNA axes, leading to the regulation of several signaling pathways such as Wnt/beta-Catenin, PI3K/AKT/mTOR, SIRT1, and Snail-EMT. Therefore, in this article, after a brief overview of lncRNA SNHG7-miRNA-mRNA axes' contribution to cancer development, we will discuss the role of lncRNA SNHG7 in the genes expression and signaling pathways related to cancers development via acting as a ceRNA.
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