期刊
CELLULAR IMMUNOLOGY
卷 379, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2022.104576
关键词
Neutrophils; Tumor microenvironment; Metastasis; Mesenchymal stromal cells
资金
- National Key R & D Program of China [2021YFA1100600, 2018YFA0107500]
- National Natural Science Foundation of China [81930085, 32150710523, 31961133024]
- Jiangsu Province International Science and Technology Cooperation Program [BZ2019017]
- State Key Laboratory of Radiation Medicine and Protection, Soochow University [GZN1201903]
- National Center for International Research-Cambridge-Su Genomic Research Center [2017B01012]
This review summarizes the role of neutrophils in tumorigenesis, with a focus on their interaction with mesenchymal stromal cells (MSCs).
Neutrophils are the most predominant cell population in the innate immune system. The role of neutrophils in the initiation, development and metastasis of tumor has been actively studied in recent years. In cancer, neutrophils exert both pro- and anti-cancer effects, and their phenotype and function are affected by the tumor microenvironment (TME). This review aims to summarize the role of neutrophils in tumorigenesis with emphasis on their interaction with mesenchymal stromal cells (MSCs).
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