相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。CCT2 is an aggrephagy receptor for clearance of solid protein aggregates
Xinyu Ma et al.
CELL (2022)
Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy
Huijie Guo et al.
CELL DEATH AND DIFFERENTIATION (2021)
Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy
Xing Li et al.
SCIENCE ADVANCES (2021)
Polyubiquitin and ubiquitin-like signals share common recognition sites on proteasomal subunit Rpn1
Andrew J. Boughton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains
Ai Kaiho-Soma et al.
MOLECULAR CELL (2021)
UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model
Kejing Zhang et al.
NEURON (2021)
Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit
Christopher S. Morrow et al.
CELL STEM CELL (2020)
Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model
Lien Nguyen et al.
NEURON (2020)
The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy
Wan Yun Ho et al.
AUTOPHAGY (2019)
C9orf72-dependent lysosomal functions regulate epigenetic control of autophagy and lipid metabolism
Yang Liu et al.
AUTOPHAGY (2019)
Inflammation in ALS/FTD pathogenesis
Madelyn E. McCauley et al.
ACTA NEUROPATHOLOGICA (2019)
In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment
Qiang Guo et al.
CELL (2018)
Rapamycin treatment for amyotrophic lateral sclerosis Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP-ALS trial)
Jessica Mandrioli et al.
MEDICINE (2018)
Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates
Jing Sun et al.
CELL DEATH & DISEASE (2018)
Quality Control of Orphaned Proteins
Szymon Juszkiewicz et al.
MOLECULAR CELL (2018)
Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control
Rahul S. Samant et al.
NATURE (2018)
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
Ken Y. Chan et al.
NATURE NEUROSCIENCE (2017)
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss
Martin H. Schludi et al.
ACTA NEUROPATHOLOGICA (2017)
The Logic of the 26S Proteasome
Galen Andrew Collins et al.
CELL (2017)
Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins
Qihui Zhou et al.
EMBO MOLECULAR MEDICINE (2017)
Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles
Kenrick A. Waite et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter
I. Gijselinck et al.
MOLECULAR PSYCHIATRY (2016)
Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015)
D. Kliosnky
AUTOPHAGY (2016)
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
Benjamin E. Deverman et al.
NATURE BIOTECHNOLOGY (2016)
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
Yong-Jie Zhang et al.
NATURE NEUROSCIENCE (2016)
p62-and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome
Victoria Cohen-Kaplan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome
Yuan Shi et al.
SCIENCE (2016)
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
Mei Yang et al.
SCIENCE ADVANCES (2016)
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers
Ian R. A. Mackenzie et al.
ACTA NEUROPATHOLOGICA (2015)
Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity
Zhouteng Tao et al.
HUMAN MOLECULAR GENETICS (2015)
Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis
Richard S. Marshall et al.
MOLECULAR CELL (2015)
mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy
Jinghui Zhao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
Aaron Ciechanover et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2015)
Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress
Yong-Jie Zhang et al.
ACTA NEUROPATHOLOGICA (2014)
Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family
Kefeng Lu et al.
CELL (2014)
p62/Sequestosome 1 Regulates Aggresome Formation of Pathogenic Ataxin-3 with Expanded Polyglutamine
Liang Zhou et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway
Shun Kageyama et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
Aaron R. Haeusler et al.
NATURE (2014)
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
Sarah Mizielinska et al.
SCIENCE (2014)
Phosphorylation of serine 349 of p62 in Alzheimer's disease brain
Kunikazu Tanji et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
Ian R. Mackenzie et al.
ACTA NEUROPATHOLOGICA (2013)
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
Kohji Mori et al.
ACTA NEUROPATHOLOGICA (2013)
PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone
Sae-Hun Park et al.
CELL (2013)
Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
Yoshinobu Ichimura et al.
MOLECULAR CELL (2013)
The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
Kohji Mori et al.
SCIENCE (2013)
TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
Manohar Pilli et al.
IMMUNITY (2012)
Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
I-Fang Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
Xiaojie Zhang et al.
AUTOPHAGY (2011)
Autophagy: Renovation of Cells and Tissues
Noboru Mizushima et al.
CELL (2011)
Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins
Gen Matsumoto et al.
MOLECULAR CELL (2011)
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
Mariely DeJesus-Hernandez et al.
NEURON (2011)
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Alan E. Renton et al.
NEURON (2011)
Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome
Daniel Finley
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation
Zheng Ying et al.
HUMAN MOLECULAR GENETICS (2009)
Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Disease-associated prion protein oligomers inhibit the 26S proteasome
Mark Kristiansen et al.
MOLECULAR CELL (2007)
Fluorescent probes for proteolysis: Tools for drug discovery
J Neefjes et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
Y Kawaguchi et al.
CELL (2003)
Aggresome-related biogenesis of Lewy bodies
KSP McNaught et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2002)
Impairment of the ubiquitin-proteasome system by protein aggregation
NF Bence et al.
SCIENCE (2001)