4.7 Article

Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock

Thanh Nha Uyen Le et al.

Summary: This study highlights the importance of S1P transporters Mfsd2b and Spns2 in maintaining vascular integrity and homeostasis. Global deletion of these transporters leads to embryonic lethality, while postnatal deletion increases susceptibility to anaphylaxis in mice.

CELL REPORTS (2022)

Review Pharmacology & Pharmacy

Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects

Jerold Chun et al.

Summary: Lysophospholipids, particularly sphingosine 1-phosphate (S1P), act through G protein-coupled receptors (GPCRs) and have complex effects on physiological and pathophysiological events. S1PR modulators, including fingolimod, siponimod, and ozanimod, have been approved for multiple sclerosis (MS) treatment, with others like ponesimod and etrasimod in clinical development. These modulators show subtype specificity for S1PRs, influencing downstream effects, and can act as both agonists and functional antagonists.
Article Chemistry, Analytical

LICAR: An Application for Isotopic Correction of Targeted Lipidomic Data Acquired with Class-Based Chromatographic Separations Using Multiple Reaction Monitoring

Liang Gao et al.

Summary: Lipidomics is an important field in biomedical and clinical research, requiring reliable quantification of lipid species. Different chromatography techniques are used in lipidomics, and isotopic correction is essential for accurate quantitation.

ANALYTICAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

Deletion of Mfsd2b impairs thrombotic functions of platelets

Madhuvanthi Chandrakanthan et al.

Summary: The study reveals the essential role of Mfsd2b in the release of S1P from platelets, with its deletion impairing platelet functions, particularly thrombus formation. This suggests that targeting Mfsd2b could be a potential approach for preventing thrombotic disorders.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b

Toan Q. Nguyen et al.

Summary: Erythrocytes efficiently uptake exogenous sphingosine for S1P production, with a de novo synthesis pathway also contributing to provide sphingosine. SphK1 plays a key role in facilitating sphingosine uptake by converting it into S1P in erythrocytes, with this process being irreversible. Mfsd2b utilizes a proton gradient to release S1P and its transport activity is dependent on negatively charged residues D95 and T157.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Emerging roles of lysophospholipids in health and disease

Shu Ting Tan et al.

PROGRESS IN LIPID RESEARCH (2020)

Review Immunology

Secrets and lyase: Control of sphingosine 1-phosphate distribution

Dhaval Dixit et al.

IMMUNOLOGICAL REVIEWS (2019)

Article Immunology

Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE

Hilary A. Seifert et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Review Pharmacology & Pharmacy

Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders

Jerold Chun et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

Article Biochemistry & Molecular Biology

Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease[S]

Julie D. Saba

JOURNAL OF LIPID RESEARCH (2019)

Article Biochemistry & Molecular Biology

S1P transporter SPNS2 regulates proper postnatal retinal morphogenesis

Chao Fang et al.

FASEB JOURNAL (2018)

Review Pharmacology & Pharmacy

The signalling roles of sphingosine-1-phosphate derived from red blood cells and platelets

Farhana Tukijan et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling

Ganlan Bian et al.

SCIENCE SIGNALING (2018)

Article Multidisciplinary Sciences

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Louise van der Weyden et al.

NATURE (2017)

Article Multidisciplinary Sciences

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

Alejandra Mendoza et al.

NATURE (2017)

Article Multidisciplinary Sciences

JunB is essential for IL-23-dependent pathogenicity of Th17 cells

Zafrul Hasan et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

Michael S. Donoviel et al.

FASEB JOURNAL (2015)

Article Chemistry, Analytical

Lipidomic Deep Profiling: An Enhanced Workflow to Reveal New Molecular Species of Signaling Lipids

Pradeep Narayanaswamy et al.

ANALYTICAL CHEMISTRY (2014)

Review Immunology

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

Jason G. Cyster et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)

Article Medicine, Research & Experimental

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

Shigetomo Fukuhara et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Clinical Neurology

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

Jerold Chun et al.

CLINICAL NEUROPHARMACOLOGY (2010)

Review Biotechnology & Applied Microbiology

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

Volker Brinkmann et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Multidisciplinary Sciences

EBI2 mediates B cell segregation between the outer and centre follicle

Joao P. Pereira et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish

Nick Osborne et al.

CURRENT BIOLOGY (2008)

Review Pharmacology & Pharmacy

Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases

J Chun et al.

CURRENT PHARMACEUTICAL DESIGN (2006)

Article Biochemistry & Molecular Biology

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

M Maceyka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis

M Kono et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Medicine, Research & Experimental

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

YJ Liu et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)