The role of lipids in cancer progression and metastasis

Article Immunology

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function

Lydia Dyck et al.

Summary: Obesity suppresses the activity of CD8 T cells in anti-tumor immunity, and this suppression can be partially reversed by weight loss and immunotherapy.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

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Article Multidisciplinary Sciences

C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer

Xiao-Zheng Liu et al.

Summary: Epidemiological studies have confirmed the positive association between obesity and postmenopausal breast cancer incidence. This study reveals that obesity-associated tumor formation is driven by cellular adaptation rather than the expansion of pre-existing clones. Cellular adaptation to obesity is regulated by palmitic acid and increases the tumor formation capacity of breast cancer cells. This process is epigenetically controlled through increased chromatin occupancy of the transcription factor CCAAT/enhancer-binding protein beta (C/EBPB), and it regulates cancer stem-like properties by modulating the expression of key downstream regulators.

NATURE COMMUNICATIONS (2022)

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Review Biotechnology & Applied Microbiology

Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery

Lingling Huang et al.

Summary: Lipidic prodrugs are an effective strategy to optimize the properties of therapeutic agents in cancer treatment, improving their physicochemical properties and antitumor activities while reducing systemic toxicity. However, the rational design of small-molecule lipidic prodrugs has not received enough attention. This review provides an overview of conjugation strategies for small-molecule lipidic prodrugs fabrication and highlights their rational design in response to physiological barriers of chemotherapeutic agents.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Nanoscience & Nanotechnology

Dual-Targeting of Tumor Cells and Tumor-Associated Macrophages by Palmitic Acid Modified Albumin Nanoparticles for Antitumor and Antimetastasis Therapy

Jiaxing Feng et al.

Summary: THP-PSA NPs exhibit stronger cytotoxicity against 4T1 and M2 macrophages compared with THP-HSA NPs in vitro. In vivo, MDSCs infiltration and immunosuppressive cytokines secretion significantly decrease after effective elimination of TAMs through THP-PSA NPs treatment, accompanied by an increase in immunostimulatory cytokine expression.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Biochemistry & Molecular Biology

Dietary intake of monounsaturated and polyunsaturated fatty acids is related to the reduced risk of esophageal squamous cell carcinoma

Yu-Xuan Tang et al.

Summary: This study found that higher intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) was associated with a lower risk of esophageal squamous cell carcinoma (ESCC), while saturated fatty acid (SFA) intake was significantly associated with a reduced risk of ESCC among non-drinkers. Dietary fat intake was not related to ESCC risk.

LIPIDS IN HEALTH AND DISEASE (2022)

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Article Multidisciplinary Sciences

β-Hydroxybutyrate suppresses colorectal cancer

Oxana Dmitrieva-Posocco et al.

Summary: The study identifies a metabolite signalling pathway that can be used as a strategy for preventing and treating colorectal cancer. Ketogenic diets and the ketone body BHB show a strong inhibitory effect on tumor growth by reducing cell proliferation. The findings suggest that BHB-triggered pathway could play a crucial role in regulating intestinal tumorigenesis.

NATURE (2022)

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Article Genetics & Heredity

HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

Xiaodong Lu et al.

Summary: The study reveals that HOXB13 suppresses lipogenic transcriptional program in prostate cancer through HDAC3 recruitment, which inhibits tumor metastasis. Loss or mutation of HOXB13 leads to lipid accumulation in PCa cells, promoting cell motility and tumor metastasis. This study provides important insights into the roles of HOXB13 in prostate cancer progression and metastasis.

NATURE GENETICS (2022)

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Article Gastroenterology & Hepatology

ATP-citrate lyase regulates stemness and metastasis in hepatocellular carcinoma via the Wnt/β-catenin signaling pathway

Qin Han et al.

Summary: ACLY is highly expressed in HCC and LTICs, and is correlated with poor prognosis, progression, and metastasis in patients. ACLY regulates the stemness and metastatic properties of HCC cells through modulating the Wnt/β-catenin signaling pathway.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2021)

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Article Oncology

The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG

Haobin Ye et al.

Summary: The liver provides a unique microenvironment for leukemia cells to acquire metabolic properties that confer increased resistance to chemotherapy. Adaptations in the liver induce metabolic changes that protect leukemia cells from conventional therapies, suggesting that overcoming liver-specific metabolic changes may improve treatment outcomes for leukemia patients.

CANCER DISCOVERY (2021)

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Review Biochemistry & Molecular Biology

The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis

Aneesha Kulkarni et al.

Summary: Obesity is associated with an increased risk and poorer prognosis for various types of cancer. Obesity-related immune dysfunction, including chronic adipose inflammation and perturbations of immune cell development and function, plays a role in promoting tumor growth. While the impact of adipose tissue inflammation on cancer risk in obese individuals is well-known, the effects of obesity on immune cell infiltration and activity within the tumor microenvironment remain underexplored. This review highlights the importance of both adipose-mediated inflammatory signaling and intratumoral immunosuppressive signaling in obesity-induced cancer risk, progression, and metastasis.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Targeting metastatic cancer

Karuna Ganesh et al.

Summary: Improved understanding of metastases biology has led to advancements in targeting and treating both micro- and macrometastases. Recent studies have identified the unique biology of metastasis-initiating cells, providing new opportunities for developing more effective treatment strategies through cancer sequencing, mechanistic studies, and clinical trials. These insights offer potential for better outcomes in targeting metastatic relapse and improving patient survival.

NATURE MEDICINE (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

MSC-induced lncRNA AGAP2-AS1 promotes stemness and trastuzumab resistance through regulating CPT1 expression and fatty acid oxidation in breast cancer

Jing Han et al.

Summary: Trastuzumab resistance poses a significant challenge in treating HER-2-positive breast cancer. This study reveals that MSC-induced upregulation of AGAP2-AS1 promotes stemness and trastuzumab resistance through activating FAO. AGAP2-AS1 may serve as a promising predictive biomarker and therapeutic target for these patients.

ONCOGENE (2021)

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Article Oncology

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis

Lindsay A. Broadfield et al.

Summary: The study indicates that high-fat intake can lead to metabolic changes in the liver, including increased glucose uptake and lactate secretion. Furthermore, the research suggests that fat can induce metabolic changes in nontransformed liver cells similar to those found in hepatocellular carcinoma (HCC).

CANCER RESEARCH (2021)

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Article Cell Biology

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

Xingzhe Ma et al.

Summary: Understanding the mechanisms of how T cells become dysfunctional in a tumor microenvironment is crucial for cancer immunotherapy. This study found that CD36 expression in tumor-infiltrating CD8(+) T cells, induced by TME cholesterol, is associated with tumor progression and poor survival, and that genetic ablation of Cd36 in these T cells leads to enhanced tumor eradication. Targeting CD36 or inhibiting ferroptosis could restore T cell function and enhance antitumor efficacy, especially in combination with anti-PD-1 antibodies.

CELL METABOLISM (2021)

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Article Multidisciplinary Sciences

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

Gloria Pascual et al.

Summary: The study suggests that dietary palmitic acid (PA), but not oleic acid or linoleic acid, may promote metastasis in oral carcinomas and melanoma in mice. The PA-induced prometastatic memory requires the fatty acid transporter CD36 and is associated with stable deposition of histone H3 lysine 4 trimethylation by methyltransferase Set1A. Furthermore, the proregenerative state of tumor-activated Schwann cells induced by PA may play a role in long-term stimulation of metastasis.

NATURE (2021)

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Article Multidisciplinary Sciences

Low glycaemic diets alter lipid metabolism to influence tumour growth

Evan C. Lien et al.

Summary: Dietary interventions can impact tumour growth by altering metabolite levels in the tumour microenvironment. While caloric restriction and a ketogenic diet have different effects on tumour growth inhibition, with caloric restriction affecting lipid levels and fatty acid balance, the ketogenic diet influences tumour fatty acid desaturation and composition.

NATURE (2021)

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Article Biotechnology & Applied Microbiology

Anti-cancer and anti-inflammatory effects elicited by short chain fatty acids produced by Escherichia coli isolated from healthy human gut microbiota

Atchareeya Nakkarach et al.

Summary: The study isolated SCFA producing bacteria from healthy human microbiota and investigated their effects on cancer cells and inflammatory responses. Escherichia coli KUB-36 was found to produce seven SCFA extracellularly, with acetic acid as the main SCFA. The metabolites from KUB-36 exhibited potent cytotoxic effects on MCF7 breast cancer cells and modulated inflammatory responses in macrophage cells.

MICROBIAL CELL FACTORIES (2021)

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Article Multidisciplinary Sciences

Lipid signalling enforces functional specialization of Treg cells in tumours

Seon Ah Lim et al.

Summary: Regulatory T cells play a crucial role in immune tolerance and immunosuppression in the tumor microenvironment. Inhibiting lipid synthesis dependent on SREBPs in T-reg cells can enhance antitumor immune responses without autoimmune toxicity, and deletion of SCAP in these cells inhibits tumor growth and enhances immunotherapy. SCAP and SREBPs signaling regulate lipid synthesis and inhibitory receptor signaling in T-reg cells, pointing to new ways of targeting these cells for cancer therapy.

NATURE (2021)

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Article Biochemistry & Molecular Biology

PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer

Laura C. A. Galbraith et al.

Summary: The study demonstrates the association between PPARG and metastasis in prostate cancer, with PPARG over-expression leading to increased levels of AKT3, which in turn enhances PGC1α localization in the nucleus, driving mitochondrial biogenesis and providing higher energetic output for tumor cell progression towards metastasis through EMT.

ONCOGENE (2021)

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Article Cell Biology

Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells

Jianmin Peng et al.

Summary: Obesity promotes the incidence of oral squamous cell carcinoma by altering the immune microenvironment and increasing the number of myeloid-derived suppressor cells (MDSCs). Targeting MDSCs in cancer immunotherapy may have greater efficacy in obese patients with OSCC.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction

Federico Giulitti et al.

Summary: In this study, the researchers found that oleic acid has anticancer effects on hepatocellular carcinoma cells, inducing apoptosis, necrosis, and senescence, while also reducing cell migration and invasion of HCC cells. Additionally, oleic acid has no significant effects on healthy cells. Furthermore, the study suggests that the effects of oleic acid on HCC cells are partly dependent on autophagy reduction.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

Sophie M. Poznanski et al.

Summary: NK cells play a central role in anti-tumor immunity, but their dysfunction in the tumor microenvironment is a major barrier for cancer immunotherapies. Research showed that human NK cell dysfunction in the tumor microenvironment is caused by suppression of glucose metabolism, and activating the antioxidant pathway can restore NK cell function and enhance anti-tumor activity. Additionally, expanded NK cells with metabolic flexibility not only sustained metabolic fitness but also improved tumor killing in response to nutrient deprivation, showing the potential for exploiting metabolic flexibility in cancer immunotherapy.

CELL METABOLISM (2021)

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Review Cell Biology

Lipid metabolism in cancer: New perspectives and emerging mechanisms

Lindsay A. Broadfield et al.

Summary: Tumors undergo metabolic changes to support growth, and increasing focus on cancer lipid metabolism has revealed mechanisms promoting tumor growth and survival that are distinct from traditional cellular bioenergetics. Targeting lipid metabolism for anticancer therapy shows promise, but there are still unanswered questions in this field.

DEVELOPMENTAL CELL (2021)

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Article Cell Biology

Lipidomics reveals that sustained SREBP-1-dependent lipogenesis is a key mediator of gefitinib-acquired resistance in EGFR-mutant lung cancer

Chuncao Xu et al.

Summary: The study shows that gefitinib downregulates Sterol Regulator Element Binding (SREBP1) in therapy-sensitive cells but not in cells with acquired resistance. Lipidomics analysis reveals different changes in lipid composition in gefitinib-sensitive and acquired-resistant cells. Inhibition of SREBP1 sensitizes EGFR-mutant therapy-resistant NSCLC to gefitinib.

CELL DEATH DISCOVERY (2021)

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Article Biochemistry & Molecular Biology

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

Jarrett R. Remsberg et al.

Summary: The covalent inhibitor ABD957 selectively impairs N-Ras depalmitoylation in AML cells, showing potential as a targeted therapy for NRAS-mutant cancers. It acts on dynamically palmitoylated proteins at the plasma membrane, causing partial effects on N-Ras palmitoylation with greater proteome selectivity compared to Palmostatin M. Additionally, ABD957 inhibits N-Ras signaling and AML cell growth, synergizing with MEK inhibition.

NATURE CHEMICAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence

Geraldine Luis et al.

Summary: The study revealed that SCD1 and FABP4 play essential roles in tumor recurrence by enhancing antioxidant and anti-ferroptotic resources. Inhibiting lipid transport and targeting SCD1 can effectively reduce tumor regrowth.

REDOX BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Palmitoylation as a Key Regulator of Ras Localization and Function

Carla Busquets-Hernandez et al.

Summary: Ras proteins rely on membrane association for proper function, a process tightly regulated by reversible palmitoylation that influences their distribution and compartmentalization within membrane subdomains. Further research into the regulatory mechanisms of protein lipidation is likely to provide new insights into the functional role of these modifications and potentially lead to novel therapeutic approaches.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Medicine, General & Internal

Association of Obesity With Survival Outcomes in Patients With Cancer A Systematic Review and Meta-analysis

Fausto Petrelli et al.

Summary: Obesity is associated with increased mortality in cancer patients overall, but patients with obesity and certain types of cancer such as lung cancer, renal cell carcinoma, and melanoma may have better survival outcomes compared to non-obese patients with the same cancers. Weight-reducing strategies could potentially help reduce mortality in these patients.

JAMA NETWORK OPEN (2021)

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Article Oncology

PPARα Agonist Fenofibrate Enhances Cancer Vaccine Efficacy

Arezki Chekaoui et al.

Summary: The PPAR alpha agonist fenofibrate was shown to improve cancer vaccine efficacy by reprogramming tumor cells to increase fatty acid metabolism and provide T cells access to glucose in the tumor microenvironment. Timing of treatment with fenofibrate was crucial in modifying tumor-infiltrating lymphocyte metabolism and enhancing the vaccine's ability to slow tumor progression.

CANCER RESEARCH (2021)

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Article Cell Biology

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

Emeline Dierge et al.

Summary: Excess uptake of specific polyunsaturated fatty acids can selectively induce ferroptosis in cancer cells under acidic conditions, potentially serving as an adjuvant antitumor modality to complement pharmacological approaches.

CELL METABOLISM (2021)

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Article Immunology

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

Shihao Xu et al.

Summary: The accumulation of lipids in the tumor microenvironment is associated with dysfunction of CD8(+) T cells, mediated in part by the CD36 receptor and its promotion of lipid uptake and peroxidation. Inhibiting p38 kinase or resolving lipid peroxidation may restore effector T cell functions and provide a potential therapeutic avenue for immunotherapies.

IMMUNITY (2021)

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Review Biochemistry & Molecular Biology

Effects of Dietary n-3 and n-6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis

Kamila P. Liput et al.

Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Cancer cells escape p53's tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation

Jun Tang et al.

Summary: This study discusses the importance of inactivation of tumor-suppressor genes in oncogenesis, as well as the role of a novel epigenetic regulatory mechanism in p53 inactivation.

ONCOGENE (2021)

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Article Cell Biology

IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R

Chenyang Qiao et al.

Summary: HOXA13 is a prognostic biomarker in CRC patients, and plays a critical role in promoting CRC metastasis by transactivating ACLY and IGF1R. Targeting the IGF1-HOXA13-IGF1R positive feedback loop may provide a potential therapeutic strategy for treating HOXA13-driven CRC metastasis.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

Miyeko D. Mana et al.

Summary: Obesity is a known risk factor for cancer in many tissues, and a high-fat diet can promote the regeneration and tumorigenesis of intestinal stem cells. PPAR alpha and PPAR delta contribute to the response to a high-fat diet in ISCs by inducing a downstream fatty acid oxidation metabolic program. Inhibiting the activated FAO program may provide a therapeutic opportunity to counteract the effects of a high-fat diet on ISCs and intestinal tumorigenesis.

CELL REPORTS (2021)

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Article Biochemistry & Molecular Biology

Increased glycolysis is an early consequence of palmitate lipotoxicity mediated by redox signaling

Pamela A. Kakimoto et al.

Summary: Exposure to toxic levels of fatty acids leads to cell damage and death, contributing to the pathogenesis of the metabolic syndrome. Lipotoxicity induces changes in mitochondrial morphology and increases glycolytic flux in cells, while oxidative phosphorylation remains unchanged.

REDOX BIOLOGY (2021)

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Review Oncology

PPAR-γ Modulators as Current and Potential Cancer Treatments

Tiange Chi et al.

Summary: PPARs are lipid sensors and metabolic regulators, with PPAR-γ showing potential in inhibiting cell proliferation, inducing apoptosis, and disrupting inflammation. However, safety concerns including drug interactions need to be addressed for clinical applications.

FRONTIERS IN ONCOLOGY (2021)

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Review Cell Biology

Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function

Garrison Komaniecki et al.

Summary: Post-translational acylation of lysine side chains, particularly by long-chain fatty acyl groups, is an important mechanism of protein regulation that affects protein affinity for specific cellular membranes. The full biological function of lysine fatty acylation is still not completely understood despite advancements in research over the past 30 years.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Lipid metabolism in metastasis and therapy

Miguel Martin-Perez et al.

Summary: Changes in lipid metabolism play a key role in cancer initiation, aggressiveness, and metastasis. High fat availability and altered lipid metabolism can promote cancer metastasis by providing energy for cancer cells, enhancing their survival mechanisms, and inhibiting immune surveillance. Reprogramming of fat metabolism in cancer cells and intratumor immune cells presents new pharmacological opportunities for treating metastasis.

CURRENT OPINION IN SYSTEMS BIOLOGY (2021)

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Article Oncology

Fatty acid synthesis is required for breast cancer brain metastasis

Gino B. Ferraro et al.

Summary: Ferraro et al. found that fatty acid synthesis is crucial for brain cancer metastasis, and inhibiting this process can reduce the metastatic growth of breast cancer cells in the brain. Metabolic adaptations required for brain metastatic breast cancer growth may introduce vulnerabilities that can be exploited for therapy, as shown by differences in nutrient availability across metastatic sites.

NATURE CANCER (2021)

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Article Biochemistry & Molecular Biology

ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis

Valery Adorno-Cruz et al.

Summary: The study revealed that miR-206 inhibits ITGA2 to reduce breast cancer stemness and metastasis. Knockdown of ITGA2 suppressed self-renewal, cell cycling, migration, invasion, and lung metastasis, related to CCND1 and ACLY.

GENES & DISEASES (2021)

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Article Medicine, General & Internal

First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

Gerald Falchook et al.

Summary: The study aimed to determine the MTD and RP2D of oral FASN inhibitor TVB-2640 and evaluate its safety and efficacy in monotherapy and in combination with paclitaxel. Results showed potent FASN inhibition with manageable toxicity primarily affecting skin and eyes, supporting further investigation particularly in KRASMUT lung, ovarian, and breast cancer patients.

ECLINICALMEDICINE (2021)

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Article Oncology

Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration

Sheri A. C. McDowell et al.

Summary: Quail and colleagues demonstrate that obesity leads to impairment of vascular integrity through neutrophil-dependent mechanisms, facilitating breast cancer metastasis to the lungs. Targetable mechanisms underlying cancer progression in the obese population are revealed.

NATURE CANCER (2021)

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Article Oncology

LXR alpha activation and Raf inhibition trigger lethal lipotoxicity in liver cancer

Ramona Rudalska et al.

Summary: The research demonstrates that pharmacologically induced lipotoxicity through activation of LXR alpha and inhibition of Raf-1 is an effective metabolic therapeutic strategy for hepatocellular carcinoma. By disrupting fatty acid desaturation and inducing lethal lipotoxicity, therapy resistance in HCC can be overcome.

NATURE CANCER (2021)

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Article Cell Biology

The negative effect of lipid challenge on autophagy inhibits T cell responses

Ignacio Guerrero-Ros et al.

AUTOPHAGY (2020)

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Article Cell Biology

SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase

Li Xiu Xu et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity

Yurena Vivas-Garcia et al.

MOLECULAR CELL (2020)

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Review Oncology

A systematic review and meta-analysis of the 2007 WCRF/AICR score in relation to cancer-related health outcomes

M. Solans et al.

ANNALS OF ONCOLOGY (2020)

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Article Oncology

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

Jessica C. Casciano et al.

BRITISH JOURNAL OF CANCER (2020)

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Review Oncology

Reprogramming of fatty acid metabolism in cancer

Nikos Koundouros et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Article Oncology

IL-17A promotes fatty acid uptake through the IL-17A/IL-17RA/p-STAT3/FABP4 axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment

Chunyan Yu et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Article Oncology

Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages

Pan Su et al.

CANCER RESEARCH (2020)

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Article Oncology

Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance

Abir Mukherjee et al.

CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Neutrophil Metabolic Shift during Their Lifecycle: Impact on Their Survival and Activation

Louise Injarabian et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Endocrinology & Metabolism

Myeloma Cells Down-Regulate Adiponectin in Bone Marrow Adipocytes Via TNF-Alpha

Emma Morris et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

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Article Oncology

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis

Jiao Feng et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Dysregulated lipid metabolism in hepatocellular carcinoma cancer stem cells

Alicia Bort et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Article Immunology

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Haiping Wang et al.

NATURE IMMUNOLOGY (2020)

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Review Cell Biology

Lipid Rafts: Controversies Resolved, Mysteries Remain

Ilya Levental et al.

TRENDS IN CELL BIOLOGY (2020)

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Article Multidisciplinary Sciences

TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

Cyril Corbet et al.

NATURE COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

Lipidomic Analysis of Cells and Extracellular Vesicles from High- and Low-Metastatic Triple-Negative Breast Cancer

Nao Nishida-Aoki et al.

METABOLITES (2020)

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Article Oncology

Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway

Yunhe Gao et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Cell Biology

REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors

Shuxi Qiao et al.

GENES & DEVELOPMENT (2020)

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Article Oncology

UBC12-mediatedSREBP-1 neddylation worsens metastatic tumor prognosis

Mi Jeong Heo et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Cell Biology

Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells

Jin Gong et al.

CELL DEATH & DISEASE (2020)

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Article Multidisciplinary Sciences

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

Clelia Coutzac et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

Arnaud Blomme et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?

Stephanie Venn-Watson et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

Obesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis

Shuai Li et al.

REDOX BIOLOGY (2020)

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Article Oncology

Targeting Fatty Acid Oxidation to Promote Anoikis and Inhibit Ovarian Cancer Progression

Brandon T. Sawyer et al.

MOLECULAR CANCER RESEARCH (2020)

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Article Pharmacology & Pharmacy

ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression

Meng Yuan et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Editorial Material Oncology

ASO Author Reflections: CD36 Expression Is Associated with Cancer Aggressiveness and Energy Source in Esophageal Squamous Cell Carcinoma

Tomonori Yoshida et al.

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Differences in elongation of very long chain fatty acids and fatty acid metabolism between triple-negative and hormone receptor-positive breast cancer

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DIABETOLOGE (2017)

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Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells

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CELL STEM CELL (2017)

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APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells

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CELL CHEMICAL BIOLOGY (2017)

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Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4/ROS/NF-κB/MMP-9 signaling pathway

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Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration

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ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

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Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity

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The Role of Cholesterol in Cancer

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Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

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Oleic acid-embedded nanoliposome as a selective tumoricidal agent

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COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

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Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling

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MOLECULAR CELL (2016)

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High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

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NATURE (2016)

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Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

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NATURE CHEMICAL BIOLOGY (2016)

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ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity

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NATURE CHEMICAL BIOLOGY (2016)

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Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

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Body Fatness and Cancer - Viewpoint of the IARC Working Group

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NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling

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SREBP-1 is an independent prognostic marker and promotes invasion and migration in breast cancer

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ONCOLOGY LETTERS (2016)

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Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

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Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

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SCIENTIFIC REPORTS (2016)

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Palmitoylation: a protein S-acylation with implications for breast cancer

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ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

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Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

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Lipid Metabolism, Apoptosis and Cancer Therapy

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior

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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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CD36 Binds Oxidized Low Density Lipoprotein (LDL) in a Mechanism Dependent upon Fatty Acid Binding

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A Review of Odd-Chain Fatty Acid Metabolism and the Role of Pentadecanoic Acid (C15:0) and Heptadecanoic Acid (C17:0) in Health and Disease

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Notum deacylates Wnt proteins to suppress signalling activity

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Obesity Triggers Enhanced MDSC Accumulation in Murine Renal Tumors via Elevated Local Production of CCL2

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Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation

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ONCOTARGET (2015)

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Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer

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Scientific Reports (2015)

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Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial A Randomized Clinical Trial

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Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

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Dietary Fat Without Body Weight Gain Increases In Vivo MCF-7 Human Breast Cancer Cell Growth and Decreases Natural Killer Cell Cytotoxicity

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Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

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SCIENTIFIC REPORTS (2015)

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Prostaglandin E3 metabolism and cancer

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CANCER LETTERS (2014)

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Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer

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CANCER RESEARCH (2014)

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Obesity, Rather Than Diet, Drives Epigenomic Alterations in Colonic Epithelium Resembling Cancer Progression

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SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma

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Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer

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The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas

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Effects of a Diet Rich in n-3 Polyunsaturated Fatty Acids on Hepatic Lipogenesis and Beta-Oxidation in Mice

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A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway

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Effects of a High-Fat Diet on Spontaneous Metastasis of Lewis Lung Carcinoma in Plasminogen Activator Inhibitor-1 Deficient and Wild-Type Mice

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Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells

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27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

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Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties

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Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms

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ONCOTARGET (2013)

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Current evidence linking polyunsaturated fatty acids with cancer risk and progression

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PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice

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The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

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BRITISH JOURNAL OF CANCER (2012)

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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CELL (2012)

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Short-Chain Fatty Acids Induce Apoptosis in Colon Cancer Cells Associated with Changes to Intracellular Redox State and Glucose Metabolism

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A metabolic prosurvival role for PML in breast cancer

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Diet-Induced Obesity Alters Dendritic Cell Function in the Presence and Absence of Tumor Growth

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Statin Use and Reduced Cancer-Related Mortality

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Phospholipase signalling networks in cancer

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A Randomized Trial of Dietary Intervention for Breast Cancer Prevention

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Oleate Blocks Palmitate-Induced Abnormal Lipid Distribution, Endoplasmic Reticulum Expansion and Stress, and Insulin Resistance in Skeletal Muscle

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Effect of Obesity on Prognosis After Early-Stage Breast Cancer

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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

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Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB/c mice

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Palmitoylation of oncogenic NRAS is essential for leukemogenesis

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BLOOD (2010)

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Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice

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BRITISH JOURNAL OF CANCER (2010)

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De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

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CANCER RESEARCH (2010)

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Oleic acid promotes MMP-9 secretion and invasion in breast cancer cells

Adriana Soto-Guzman et al.

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Increased Mitochondrial Fatty Acid Oxidation Is Sufficient to Protect Skeletal Muscle Cells from Palmitate-induced Apoptosis

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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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DHHC20: a human palmitoyl acyltransferase that causes cellular transformation

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MOLECULAR MEMBRANE BIOLOGY (2010)

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The Complex and Important Cellular and Metabolic Functions of Saturated Fatty Acids

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LIPIDS (2010)

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N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRα

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)

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Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2009)

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Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model

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CANCER RESEARCH (2008)

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In rat hepatocytes, myristic acid occurs through lipogenesis, palmitic acid shortening and lauric acid elongation

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ANIMAL (2007)

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Article Biochemistry & Molecular Biology

Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in vitro and increased lung metastasis in NOD/SCID mice

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Gain of 5p15.33 is associated with progression of bladder cancer

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ONCOLOGY (2007)

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Dietary fat reduction and breast cancer outcome: Interim efficacy results from the Women's Intervention Nutrition Study

Rowan T. Chlebowski et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)

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ATP citrate lyase inhibition can suppress tumor cell growth

G Hatzivassiliou et al.

CANCER CELL (2005)

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Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erb B-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin™) in breast cancer cells with Her-2/neu oncogene amplification

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ANNALS OF ONCOLOGY (2005)

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Review Biochemistry & Molecular Biology

Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution

CN Serhan

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2005)

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Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase

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ONCOGENE (2004)

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

LL Listenberger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Biochemistry & Molecular Biology

Does a linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters?

FA Wenger et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2000)

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The role of lipids in cancer progression and metastasis

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