期刊
CELL HOST & MICROBE
卷 30, 期 10, 页码 1450-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2022.09.004
关键词
-
资金
- National Key R&D Program of China [2021YFA1301102]
- National Natural Science Foundation of China [82170495, 82070820]
- Major Science and Technology Innovation Project of Shandong Province [2018CXGC1218]
This study reveals significant abnormalities in the gut microbe composition of abdominal aortic aneurysm (AAA) patients and confirms that gut microbiota dysbiosis is an important cause of AAA. The researchers found that a specific bacterium and its metabolite can alleviate AAA development.
Abdominal aortic aneurysm (AAA) is an insidious and lethal vascular disease that lacks effective nonsurgical interventions. Gut microbiota dysbiosis plays key roles in many diseases, but its relationship with AAA has not been fully elucidated. Herein, we reveal significant abnormalities in the gut microbe composition of AAA patients and confirm that gut microbiota dysbiosis is an important cause of AAA. Specifically, R. intestinalis was significantly reduced in AAA patients. Using AAA mice, we show that R. intestinalis and its metabolite butyrate significantly reduce neutrophil infiltration and NOX2-dependent neutrophil extracellular trap formation, inflammation, and abnormal phenotypic switching of vascular smooth muscle cells in the aortic wall, thereby markedly alleviating AAA development. Our research uncovers the role and mechanism of the gut microbiota in AAA development and provides insights into AAA prophylaxis from a microecological perspective.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据