期刊
CELL COMMUNICATION AND SIGNALING
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12964-022-00986-1
关键词
Radiotherapy; Exosomes; Radioresistance; Bystander effect
类别
资金
- Natural Science Foundation of Liaoning Province [2021-MS-181, 2019-MS-06]
- Young and middle-aged scientific and technological talents support program of Shenyang City [RC200554]
Radiotherapy is commonly used in cancer treatment, but radioresistance and radiation-induced bystander effects remain challenging. Exosomes play a significant role in radiotherapy by mediating intercellular signaling pathways and participating in the mechanisms of radioresistance and radiation-induced bystander effects.
Presently, more than half of cancer patients receive radiotherapy to cure localized cancer, palliate symptoms, or control the progression of cancer. However, radioresistance and radiation-induced bystander effects (RIBEs) are still challenging problems in cancer treatment. Exosomes, as a kind of extracellular vesicle, have a significant function in mediating and regulating intercellular signaling pathways. An increasing number of studies have shown that radiotherapy can increase exosome secretion and alter exosome cargo. Furthermore, radiation-induced exosomes are involved in the mechanism of radioresistance and RIBEs. Therefore, exosomes hold great promise for clinical application in radiotherapy. In this review, we not only focus on the influence of radiation on exosome biogenesis, secretion and cargoes but also on the mechanism of radiation-induced exosomes in radioresistance and RIBEs, which may expand our insight into the cooperative function of exosomes in radiotherapy.
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