期刊
CELL
卷 185, 期 20, 页码 3789-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2022.09.005
关键词
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资金
- US National Institutes of Health, National Cancer Institute [F30 CA243480]
- National Cancer Institute within the National Institutes of Health [R01 CA255206, U24 CA248454]
- National Institutes of Health [NIH DP1AT010885]
- Israel Science Foundation [2927/21]
- Binational Science Foundation [2013332]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [818086]
- Fabrikant-Morse Families Research Fund for Humanity
- Knell Family Center for Microbiology
- Moross Integrated Cancer Center
- Swiss Society Institute for Cancer Prevention Research at the Weizmann Institute of Science
- Rising Tide Foundation
- Dr. Dvora and Haim Teitelbaum Endowment Fund
- International Collaboration Grant from the Jacki and Bruce Barron Cancer Research Scholars' Program
- Israel Cancer Research Fund
- City of Hope (COH) - Harvey L. Miller Family Foundation
- SD IRACDA-Professors of the Future [5K12GM068524-17]
- National Cancer Institute, National Institutes of Health [HHSN261201400008C, 17X146, HHSN261201500003I]
- [R00 AA020235]
- [R01 DA026334]
- [P30 MH062513]
- [P01 DA012065]
- [P50 DA026306]
- European Research Council (ERC) [818086] Funding Source: European Research Council (ERC)
- Directorate for STEM Education
- Division Of Undergraduate Education [2013332] Funding Source: National Science Foundation
This study comprehensively characterizes the cancer mycobiome in cancer patients and finds low abundances of fungi in various human cancers. The composition of fungal communities differs among cancer types and they are frequently associated with cancer cells and macrophages spatially. Comparisons with bacterial and immune communities reveal co-occurring bi-domain ecologies and distinct immune responses. The tissue and plasma mycobiomes show prognostic and diagnostic capabilities even in early stage cancers, and synergistic predictive performance with bacterial communities.
Cancer-microbe associations have been explored for centuries, but cancer-associated fungi have rarely been examined. Here, we comprehensively characterize the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 cancer types in four independent cohorts. We report fungal DNA and cells at low abundances across many major human cancers, with differences in community compositions that differ among cancer types, even when accounting for technical background. Fungal histological staining of tissue microarrays supported intratumoral presence and frequent spatial association with cancer cells and macrophages. Comparing intratumoral fungal communities with matched bacteriomes and immunomes re-vealed co-occurring bi-domain ecologies, often with permissive, rather than competitive, microenvironments and distinct immune responses. Clinically focused assessments suggested prognostic and diagnostic ca-pacities of the tissue and plasma mycobiomes, even in stage I cancers, and synergistic predictive perfor-mance with bacteriomes.
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