期刊
CARDIOVASCULAR DIABETOLOGY
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12933-022-01626-1
关键词
Cardiovascular disease; Chemokine; Chemokine CC motif ligand 7; Chronic kidney disease; Diabetes mellitus; Diabetic kidney disease
资金
- Ministry of Science and Technology, Taipei, Taiwan, ROC [MOST 110-2314-B-A49A-552-MY3, MOST107-2314-B-010-060-MY3]
- Taipei Veterans General Hospital, Taipei, Taiwan, ROC [V110C-065]
Chemokine CC motif ligand 7 (CCL7) is implicated in the development of cardiovascular disease, diabetes mellitus, and kidney disease by attracting macrophages and monocytes to contribute to inflammatory processes. However, the specific pathological signaling pathways of CCL7 need to be further investigated.
Chemokines are key components in the pathology of chronic diseases. Chemokine CC motif ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus, and kidney disease. CCL7 may play a role in inflammatory events by attracting macrophages and monocytes to further amplify inflammatory processes and contribute to disease progression. However, CCL7-specific pathological signaling pathways need to be further confirmed in these chronic diseases. Given the multiple redundancy system among chemokines and their receptors, further experimental and clinical studies are needed to clarify whether direct CCL7 inhibition mechanisms could be a promising therapeutic approach to attenuating the development of cardiovascular disease, diabetes mellitus, and kidney disease.
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