期刊
CARBON
卷 199, 期 -, 页码 110-118出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2022.07.021
关键词
MXene; Carbon nanotubes; CuMOF; Tyrosine; Electrochemical sensor; Human serum; Enzyme-free
资金
- Natural Science Foundation of China [21565022, 22174110]
- Gansu Provincial Science and Technology Project [18YF1GA050]
- Graduate Cultivating and Curriculum Reform Program of Northwest Normal University [2021KGLX01005]
- Undergraduate Course Design
An enzyme-free electrochemical sensor based on MXene/CNTs/CuMOF composite was developed for the detection of tyrosine. The sensor has good linearity and stability, and can be used for the detection of tyrosine in human serum.
Tyrosine is the precursor of some neurotransmitters such as thyroxine and dopamine. It has the effect of regulating emotions and stimulating the nervous system. Changes in tyrosine levels in the human body are associated with certain diseases. Therefore, it is very necessary to prepare a new type of tyrosine sensor. In this work, an enzyme-free electrochemical sensor based on MXene/CNTs/CuMOF composite was developed for the detection of tyrosine. Embedding carbon nanotubes (CNTs) into MXene effectively prevented the aggregation of MXene sheets. Further modification of MXene/CNTs materials with CuMOF octahedral particles with porous structure can improve the porosity and catalytic capability of the composites. Under the optimal detection conditions, the prepared sensor has good linearity in the detection of tyrosine within range 0.53 mu M-232.46 mu M with a limit of detection (LOD) of 0.19 mu M. The stability and selectivity of the sensor is high, and can be used to detect tyrosine in human serum.
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