Strategies for sustained release of heparin: A review

Article Chemistry, Applied

γ-Cyclodextrin-based polypseudorotaxane hydrogels for ophthalmic delivery of flurbiprofen to treat anterior uveitis

Guihua Fang et al.

Summary: This study developed polypseudorotaxane hydrogels for the treatment of anterior uveitis, which showed promising results in terms of sustained release and enhanced therapeutic efficacy.

CARBOHYDRATE POLYMERS (2022)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Cyclodextrin-based host-guest supramolecular hydrogels for local drug delivery

Guihua Fang et al.

Summary: This review summarizes the application of CD-based host-guest supramolecular hydrogels in local drug delivery. It covers the formation of supramolecular hydrogels with different types of CD, the physicochemical characteristics of these hydrogels, and their application in various administration routes. The review also discusses the challenges and future directions for the clinical translation of CD-based host-guest supramolecular hydrogels.

COORDINATION CHEMISTRY REVIEWS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Goserelin/PLGA solid dispersion used to prepare long-acting microspheres with reduced initial release and reduced fluctuation of drug serum concentration in vivo

Tianyang Ren et al.

Summary: This study successfully prepared Goserelin-loaded long-acting microspheres with reduced initial release and prolonged drug release time using the hot-melt extrusion and oil-in-water methods. The Goserelin molecules in the microspheres existed as molecular or amorphous state, resulting in lower burst release and stable drug release in vivo.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

添加到收藏夹

Article Engineering, Biomedical

Epigallocatechin gallate mediated sandwich-like coating for mimicking endothelium with sustained therapeutic nitric oxide generation and heparin release

Bo Zhang et al.

Summary: The study developed a sandwich-like layer-by-layer coating using chitosan and heparin as polyelectrolytes, along with the embedding of an EGCG/Cu complex, which demonstrated enhanced anticoagulation durability, suppression of inflammatory response, and support for endothelial cell growth.

BIOMATERIALS (2021)

添加到收藏夹

Article Engineering, Biomedical

Covalent grafting of PEG and heparin improves biological performance of electrospun vascular grafts for carotid artery replacement

Tonghe Zhu et al.

Summary: The study synthesized PEUU@PEG-Hep vascular graft with good biocompatibility and blood compatibility, and the covalent grafting of PEG and heparin significantly enhanced endothelial cell adhesion, spreading, and proliferation, as well as improved the grafts' ability to prevent platelet deposition.

ACTA BIOMATERIALIA (2021)

添加到收藏夹

Article Chemistry, Physical

Chitosan/heparin polyelectrolyte complexes as ion-paring approach to encapsulate heparin in orally administrable SLN: In vitro evaluation

Eleonora Maretti et al.

Summary: This study aims to enhance the oral bioavailability of hydrophilic drugs by encapsulating high molecular weight heparin in Chitosan/Heparin Polyelectrolyte Complexes (PEC) and subsequently in Solid Lipid Nanoparticles (SLN). The hybrid PEC-SLN showed pH-controlled drug release, low toxicity, and rapid internalization in CaCo-2 cells, making them a promising candidate for further in vivo investigations on the systemic bioavailability of oral heparin.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Topical delivery of heparin from PLGA nanoparticles entrapped in nanofibers of sericin/gelatin scaffolds for wound healing

Duygu Deniz Akolpoglu Basaran et al.

Summary: Skin regeneration is a crucial issue in tissue engineering, and developing effective biomaterials for enhanced regeneration while meeting the healing requirements is a challenge. This study encapsulated heparin in PLGA nanoparticles and incorporated them into Ser/Gel nanofibers to create a controlled release system promoting skin tissue regeneration. Sericin addition slowed down scaffold degradation, and the scaffold with a Ser/Gel ratio of 1/2 was considered the most promising candidate due to its proper fiber morphology, high water retention, and low degradation degree.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Article Hematology

Weight-adjusted tinzaparin for venous thromboembolism prophylaxis in bariatric surgery patients weighing 160 kg or more

A. Li et al.

Summary: The study concluded that weight-adjusted tinzaparin is safe and effective for prophylaxis against VTE in bariatric surgery patients weighing over 160kg, with low risks of bleeding and VTE events.

THROMBOSIS RESEARCH (2021)

添加到收藏夹

Review Anatomy & Morphology

Applications of zeolitic imidazolate framework-8 (ZIF-8) in bone tissue engineering: A review

Vahid Hoseinpour et al.

Summary: There is limited research on the usage of zeolitic imidazolate framework-8 (ZIF-8) in bone tissue engineering, with this review focusing on its application and synthesis methods, biocompatibility, and medical applications. The literature review covers previous applications of ZIF-8 in bone tissue engineering, discussing its use in bone scaffolds and drug delivery systems, as well as highlighting future perspectives.

TISSUE & CELL (2021)

添加到收藏夹

Review Oncology

Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field

Fernanda Andrade et al.

Summary: Cancer remains the second leading cause of death globally, with the major obstacles in treatment being chemotherapy side effects and drug resistance. Research is ongoing to develop new formulations for localized drug delivery at tumor sites to improve treatment outcomes. Stimuli-responsive hydrogels, such as pH-, light-, ionic strength-, and magnetic-responsive hydrogels, show promising results in the localized control and treatment of cancer.

CANCERS (2021)

添加到收藏夹

Article Chemistry, Physical

tert-Butylamine functionalized MCM-41 mesoporous nanoparticles as drug carriers for the controlled release of cyclophosphamide anticancer drug

Zahra Shariatinia et al.

Summary: Mesoporous MCM-41 nanoparticles functionalized with TBA were used as efficient drug delivery systems for the anticancer drug CP. The drug release was influenced by the environment, with the greatest release in alkaline conditions, moderate release in neutral medium, and the lowest release in acidic solution. The CP release from all carriers followed the Korsmeyer-Peppas model, and the MCM-41 nanomaterial functionalized with 17% TBA was suggested as the most desirable system.

SURFACES AND INTERFACES (2021)

添加到收藏夹

Review Engineering, Biomedical

Multi-functional silica-based mesoporous materials for simultaneous delivery of biologically active ions and therapeutic biomolecules

Hui Zhu et al.

Summary: In summary, mesoporous silica-based materials, especially MBGs, are promising for biomedical applications due to their bioactivity, biocompatibility, tunable composition, and controllable nanoporosity. Research has shown that MBGs can be doped with therapeutic ions and loaded with specific biomolecules to achieve controllable drug release kinetics. Co-delivery of ions and biomolecules using MBGs can offer synergistic effects for improved therapeutic outcomes.

ACTA BIOMATERIALIA (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Supramolecular engineering of hydrogels for drug delivery

Stephane Bernhard et al.

Summary: Supramolecular binding motifs are increasingly utilized in the design of biomaterials, particularly in drug delivery systems. Rational engineering of specific associations enables injectable or sprayable hydrogels, achieving minimally invasive administration in drug delivery.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Heparin beyond anti-coagulation

Daohong Chen

Summary: Heparin has been a mainstream anticoagulant for over eight decades, and recent studies have shown its potential in various clinical applications beyond anticoagulation. This article presents a comprehensive update on the expanded applications of heparin agents, showcasing their importance in treating severe illnesses.

CURRENT RESEARCH IN TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Biomedical application of responsive 'smart' electrospun nanofibers in drug delivery system: A minireview

Nurul Huda Kamsani et al.

Summary: Electrospinning technique is a versatile method for producing continuous nanofibers, which has become cost-effective and drawn keen interests in the biomedical field. Smart electrospun pH-responsive nanofibers have various applications in emerging biomedical developments such as cancer drug targeting, wound healing, and vaginal drug delivery.

ARABIAN JOURNAL OF CHEMISTRY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Pharmacological and clinical application of heparin progress: An essential drug for modern medicine

Min Qiu et al.

Summary: Heparin, as the earliest and most widely used anticoagulant and antithrombotic drug, plays a significant role in clinical applications but comes with a range of adverse reactions. Modern research emphasizes the various pharmacological activities and clinical applications of heparin, providing guidance for its development in the medical field.

BIOMEDICINE & PHARMACOTHERAPY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Application of commercially available mesoporous silica for drug dissolution enhancement in oral drug delivery

Ana Baumgartner et al.

Summary: Developing oral drug delivery for poorly water-soluble active pharmaceutical ingredients is challenging. Formulating such compounds into amorphous solid dispersions is one strategy, with porous materials like mesoporous silica being investigated as possible carriers. Non-ordered silica, already regarded as safe, may facilitate faster market entry for products containing solid dispersions.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Aqueous core microcapsules as potential long-acting release systems for hydrophilic drugs

Raghad M. Abuhamdan et al.

Summary: By optimizing the internal phase separation process, aqueous core microcapsules with polymeric shells composed of PLGA or PLA can serve as controlled release platforms for hydrophilic drugs. Varying polymer properties and formulation compositions can dramatically impact the characteristics and release durations of the produced microcapsules. These microcapsules can be tailored for long-acting encapsulation of a variety of hydrophilic drugs.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Practical quality attributes of polymeric microparticles with current understanding and future perspectives

Ripesh Bhujel et al.

Summary: This review outlines the quality attributes of polymeric microparticles, various preparation methods, and innovative approaches to overcome manufacturing issues associated with traditional methods. In addition, the in vitro-in vivo correlation of parenteral microparticles as an essential quality parameter in formulation development is discussed, along with the elaboration of different simulation models to define the overall quality of microparticles.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

添加到收藏夹

Review Engineering, Environmental

Hydrogels: Synthesis, Classification, Properties and Potential Applications-A Brief Review

Balbir Singh Kaith et al.

Summary: Hydrogels are three-dimensional structures with hydrated polymeric networks that have superabsorbent properties. They have been extensively researched worldwide for biomedical, pharmaceutical, and environmental applications. Super intelligent hydrogels are gaining significant interest in various biomedical applications. This review covers the properties, classification, preparation methods, important literature, and miscellaneous applications of hydrogels.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2021)

添加到收藏夹

Review Immunology

Potential toxicity of nanoparticles on the reproductive system animal models: A review

Marziyeh Ajdary et al.

Summary: Nanotechnology has been widely applied in various fields over the past two decades, but concerns about the toxicity of nanoparticles have hindered their use. Nanoparticles not only have negative effects on organs but can also lead to abortion in women, impact fetal development, and harm the male reproductive system. Understanding the impact of nanoparticles on the reproductive system is crucial for their safe use.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2021)

添加到收藏夹

Article Polymer Science

Development of prolonged drug delivery system using electrospun cellulose acetate/polycaprolactone nanofibers: Future subcutaneous implantation

Mohammed Ahmad Wsoo et al.

Summary: The study successfully developed an IDDS composed of CA and PCL nanofibers, with the PCL membrane playing a crucial role in enhancing the mechanical properties of the implant and drug release kinetics.

POLYMERS FOR ADVANCED TECHNOLOGIES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

Yujie Shi et al.

Summary: The development of long-acting parenteral formulations (LAPFs) aims to improve drug pharmacokinetics and therapeutic efficacy in treating chronic diseases. LAPFs have been shown to extend therapeutic half-life and enhance patient adherence, leading to positive treatment outcomes. Despite progress in designing effective LAPFs, challenges and prospects remain in manipulation of in vivo clearance and drug release to achieve long-acting effects.

ACTA PHARMACEUTICA SINICA B (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Biocompatible, Crystalline, and Amorphous Bismuth-Based Metal-Organic Frameworks for Drug Delivery

Claudia Orellana-Tavra et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Advanced delivery strategies facilitating oral absorption of heparins

Guihua Fang et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

添加到收藏夹

Review Food Science & Technology

Two-Dimensional Layered Nanomaterial-Based Electrochemical Biosensors for Detecting Microbial Toxins

Zhuheng Li et al.

TOXINS (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Layer -by -layer technique for enhancing physicochemical properties of actives

Pravin Shende et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Ultra-small Fe3O4 nanoparticles for nuclei targeting drug delivery and photothermal therapy

Wen Wen et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Drug delivery systems based on nanoparticles and related nanostructures

Ana V. Vujačić Nikezić et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Development of Lipid-Polymer Hybrid Nanoparticles for Improving Oral Absorption of Enoxaparin

Bo Tang et al.

PHARMACEUTICS (2020)

添加到收藏夹

Review Engineering, Biomedical

Emerging nanotherapeutics for antithrombotic treatment

Zhiqiang Zhao et al.

BIOMATERIALS (2020)

添加到收藏夹

Review Chemistry, Analytical

Application trends of nanofibers in analytical chemistry

Bo-Tao Zhang et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Graphene nanoribbons: A promising nanomaterial for biomedical applications

Asha P. Johnson et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Review Peripheral Vascular Disease

The applications of heparin in vascular tissue engineering

Saba Aslani et al.

MICROVASCULAR RESEARCH (2020)

添加到收藏夹

Review Chemistry, Analytical

Mo-Based Layered Nanostructures for the Electrochemical Sensing of Biomolecules

Rayhane Zribi et al.

SENSORS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis (3-aminopropyl) ammonium allows sustained release of heparin

Daichi Ito et al.

HELIYON (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Perioperative Bleeding in Patients With Acute Coronary Syndrome Treated With Fondaparinux Versus Low-Molecular-Weight Heparin Before Coronary Artery Bypass Grafting

Sorosh Khodabandeh et al.

AMERICAN JOURNAL OF CARDIOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Nanofibers for Biomedical and Healthcare Applications

Rahimeh Rasouli et al.

MACROMOLECULAR BIOSCIENCE (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Micelle-Embedded Layer-by-Layer Coating with Catechol and Phenylboronic Acid for Tunable Drug Loading, Sustained Release, Mild Tissue Response, and Selective Cell Fate for Re-endothelialization

Jiang Lu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

添加到收藏夹

Article Materials Science, Biomaterials

Novel heparin-loaded mesoporous tubular micromotors formed via template-assisted electrochemical deposition

Qi Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

添加到收藏夹

Article Obstetrics & Gynecology

Timing of initiation of low-molecular-weight heparin administration in pregnant women with antiphospholipid syndrome: a randomized clinical trial of efficacy and safety

Mohamed Ibrahem Eid et al.

INTERNATIONAL JOURNAL OF WOMENS HEALTH (2019)

添加到收藏夹

Article Engineering, Biomedical

Long-term anticoagulation and selective cells adhesion surface via combination of covalent grafting and layer by layer assembly

Chaojing Li et al.

BIOMEDICAL MATERIALS (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Covalent layer-by-layer films: chemistry, design, and multidisciplinary applications

Qi An et al.

CHEMICAL SOCIETY REVIEWS (2018)

添加到收藏夹

Article Materials Science, Multidisciplinary

Crosslinked gelatin hydrogels as carriers for controlled heparin release

Lukas Gritsch et al.

MATERIALS LETTERS (2018)

添加到收藏夹

Article Materials Science, Biomaterials

Nano silver decorated polyacrylamide/dextran nanohydrogels hybrid composites for drug delivery applications

Kalyani Prusty et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

添加到收藏夹

Meeting Abstract Economics

COST-EFFECTIVENESS OF EDOXABAN COMPARED WITH DALTEPARIN FOR THE TREATMENT OF CANCER-ASSOCIATED VENOUS THROMBOEMBOLISM

J. Ma et al.

VALUE IN HEALTH (2018)

添加到收藏夹

Review Surgery

Low molecular weight heparin for the prevention of deep venous thrombosis after total knee arthroplasty: A systematic review and meta-analysis

Ze-Nan Xia et al.

INTERNATIONAL JOURNAL OF SURGERY (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Clinical Applications of Carbon Nanomaterials in Diagnostics and Therapy

Kian Ping Loh et al.

ADVANCED MATERIALS (2018)

添加到收藏夹

Article Biophysics

Surface immobilization of heparin and chitosan on titanium to improve hemocompatibility and antibacterial activities

Xiangyu Zhang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Development and evaluation of thermo-sensitive hydrogel system with nanocomplexes for prolonged subcutaneous delivery of enoxaparin

Guihua Fang et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

New Applications of Heparin and Other Glycosaminoglycans

Marcelo Lima et al.

MOLECULES (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Milestone 1: Discovery and purification of heparin

Gregory B. Lim

Nature Reviews Cardiology (2017)

添加到收藏夹

Article Critical Care Medicine

Prophylaxis and Incidence of Symptomatic Deep Vein Thrombosis in Indian Patients with Sepsis: DETECT-Deep Vein Thrombosis Registry

Nagarajan Ramakrishnan

INDIAN JOURNAL OF CRITICAL CARE MEDICINE (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Porous Inorganic Drug Delivery Systems-a Review

E. Sayed et al.

AAPS PHARMSCITECH (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Heparin coatings for improving blood compatibility of medical devices

Roy Biran et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Passive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats

Shaimaa S. Ibrahim et al.

DRUG DELIVERY (2017)

添加到收藏夹

Article Chemistry, Physical

The effect of electrostatic heparin/collagen layer-by-layer coating degradation on the biocompatibility

Jialong Chen et al.

APPLIED SURFACE SCIENCE (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy

Chengjun Chen et al.

SMALL (2016)

添加到收藏夹

Review Nanoscience & Nanotechnology

Designing hydrogels for controlled drug delivery

Jianyu Li et al.

NATURE REVIEWS MATERIALS (2016)

添加到收藏夹

Review Chemistry, Medicinal

Heparin: Past, Present, and Future

Eziafa I. Oduah et al.

PHARMACEUTICALS (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Low molecular weight heparin tinzaparin antagonizes cisplatin resistance of ovarian cancer cells

Daniel Bastian Pfankuchen et al.

BIOCHEMICAL PHARMACOLOGY (2015)

添加到收藏夹

Review Engineering, Biomedical

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Kan Yue et al.

BIOMATERIALS (2015)

添加到收藏夹

Letter Medical Laboratory Technology

Anti-Xa activity in VTE patients treated with fondaparinux

Satoshi Ota

CLINICA CHIMICA ACTA (2015)

添加到收藏夹

Review Pharmacology & Pharmacy

Drug delivery from gelatin-based systems

Maytal Foox et al.

EXPERT OPINION ON DRUG DELIVERY (2015)

添加到收藏夹

Article Pharmacology & Pharmacy

Prolonged subcutaneous delivery of low molecular weight heparin based on thermoresponsive hydrogels with chitosan nanocomplexes: Design, in vitro evaluation, and cytotoxicity studies

Maja Radivojsa Matanovic et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

添加到收藏夹

Article Pharmacology & Pharmacy

Development and preclinical pharmacokinetics of a novel subcutaneous thermoresponsive system for prolonged delivery of heparin

Maja Radivojsa Matanovic et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Current strategies for sustaining drug release from electrospun nanofibers

Shih-Feng Chou et al.

JOURNAL OF CONTROLLED RELEASE (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Polymeric Nanoparticles of Enoxaparin as a Delivery System: In Vivo Evaluation in Normal Rats and in a Venous Thrombosis Rat Model

Carla Pazzini et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2015)

添加到收藏夹

Review Hematology

Medical device-induced thrombosis: what causes it and how can we prevent it?

I. H. Jaffer et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)

添加到收藏夹

Article Nanoscience & Nanotechnology

Mesoporous silica nanoparticles in drug delivery and biomedical applications

Ying Wang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses

Qi Ying Lean et al.

PLOS ONE (2015)

添加到收藏夹

Article Orthopedics

Effects of enoxaparin and rivaroxaban on tissue survival in skin degloving injury: an experimental study

Ibrahim Azboy et al.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA (2014)

添加到收藏夹

Article Pediatrics

Effect of dalteparin, a low-molecular-weight heparin, as adjunctive therapy in patients with Kawasaki disease: a retrospective study

Yasuji Inamo et al.

BMC PEDIATRICS (2014)

添加到收藏夹

Review Chemistry, Applied

A world of low molecular weight heparins (LMWHs) enoxaparin as a promising moiety-A review

Rahul G. Ingle et al.

CARBOHYDRATE POLYMERS (2014)

添加到收藏夹

Article Materials Science, Biomaterials

Fabricating a sustained releaser of heparin using SBA-15 mesoporous silica

Wen Juan Qian et al.

JOURNAL OF MATERIALS CHEMISTRY B (2014)

添加到收藏夹

Article Critical Care Medicine

Heparin therapy reduces 28-day mortality in adult severe sepsis patients: a systematic review and meta-analysis

Changsong Wang et al.

CRITICAL CARE (2014)

添加到收藏夹

Article Pharmacology & Pharmacy

Thermoreversible in situ gelling poloxamer-based systems with chitosan nanocomplexes for prolonged subcutaneous delivery of heparin: Design and in vitro evaluation

Maja Radivojsa et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

添加到收藏夹

Article Orthopedics

Postoperative plasma D-dimer value for predicting deep venous thrombosis following hip arthroplasty with nadroparin prophylaxis

Zhihong Xu et al.

HIP INTERNATIONAL (2013)

添加到收藏夹

Review Multidisciplinary Sciences

Idraparinux or Idrabiotaparinux for Long-Term Venous Thromboembolism Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yanzhi Song et al.

PLOS ONE (2013)

添加到收藏夹

Article Medicine, Research & Experimental

Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage

Xiaoshan Shi et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2013)

添加到收藏夹

Article Nanoscience & Nanotechnology

Sustained Release of Heparin on Enlarged-Pore and Functionalized MCM-41

Mi Mi Wan et al.

ACS APPLIED MATERIALS & INTERFACES (2012)

添加到收藏夹

Article Engineering, Biomedical

Preparation of gelatin hydrogels incorporating low-molecular-weight heparin for anti-fibrotic therapy

Takashi Saito et al.

ACTA BIOMATERIALIA (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chitosan/TPP microparticles obtained by microemulsion method applied in controlled release of heparin

Alessandro F. Martins et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2012)

添加到收藏夹

Article Pharmacology & Pharmacy

Haemocompatibility improvement of metallic surfaces by covalent immobilization of heparin-liposomes

Michail Kastellorizios et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

添加到收藏夹

Article Engineering, Biomedical

In situ crosslinkable heparin-containing poly(ethylene glycol) hydrogels for sustained anticoagulant release

Aaron D. Baldwin et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2012)

添加到收藏夹

Article Hematology

Semuloparin for prevention of venous thromboembolism after major orthopedic surgery: results from three randomized clinical trials, SAVE-HIP1, SAVE-HIP2 and SAVE-KNEE

M. R. Lassen et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)

添加到收藏夹

Article Medicine, General & Internal

Semuloparin for Thromboprophylaxis in Patients Receiving Chemotherapy for Cancer

Giancarlo Agnelli et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

添加到收藏夹

Review Engineering, Biomedical

Strategies for the nanoencapsulation of hydrophilic molecules in polymer-based nanoparticles

Sandy Vrignaud et al.

BIOMATERIALS (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Biomimetic Solid Lipid Nanoparticles for Oral Bioavailability Enhancement of Low Molecular Weight Heparin and Its Lipid Conjugates: In Vitro and in Vivo Evaluation

Rishi Paliwal et al.

MOLECULAR PHARMACEUTICS (2011)

添加到收藏夹

Article Chemistry, Physical

Supramolecular hydrogels based on cyclodextrin-polymer polypseudorotaxanes: materials design and hydrogel properties

Kerh Li Liu et al.

SOFT MATTER (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Bioactive Supramolecular Hydrogel with Controlled Dual Drug Release Characteristics

Dong Ma et al.

BIOMACROMOLECULES (2010)

添加到收藏夹

Article Pharmacology & Pharmacy

Smart alginate-hydroxypropylcellulose microbeads for controlled release of heparin

A. Karewicz et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Covalently Bonded Layer-by-Layer Assembly of Multifunctional Thin Films Based on Activated Esters

Jinhwa Seo et al.

LANGMUIR (2010)

添加到收藏夹

Article Hematology

Idraparinux versus standard therapy in the treatment of deep venous thrombosis in cancer patients: A subgroup analysis of the Van Gogh DVT trial

Frederiek F. van Doormaal et al.

THROMBOSIS AND HAEMOSTASIS (2010)

添加到收藏夹

Article Materials Science, Multidisciplinary

Controlled release of heparin from blended polyurethane and silk fibroin film

Xiu-Ying Liu et al.

MATERIALS LETTERS (2009)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis and Evaluation of Pegylated Dendrimeric Nanocarrier for Pulmonary Delivery of Low Molecular Weight Heparin

Shuhua Bai et al.

PHARMACEUTICAL RESEARCH (2009)

添加到收藏夹

Article Chemistry, Physical

In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids

Zi Gu et al.

CHEMISTRY OF MATERIALS (2008)

添加到收藏夹

Review Critical Care Medicine

Heparin and low-molecular-weight heparin - Mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety

J Hirsh et al.

CHEST (2001)

添加到收藏夹

Strategies for sustained release of heparin: A review

相关参考文献

导出引文

分享论文