期刊
CARBOHYDRATE POLYMERS
卷 291, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119546
关键词
Low molecular weight heparin; Dalteparin; Enoxaparin; Nanosilver; Microbial biofilms; Anticoagulant; CVC related infections
资金
- SERB-DST [BT/07/IYBA/201319]
- IIT-Roorkee
- DBT-IYBA fellowship, Govt. of India [BT/07/IYBA/201319]
Catheter-related bloodstream infections are a major concern for hemodialysis patients. A study has developed a low molecular weight heparin coated nanosilver with dual functions as an anticoagulant and antimicrobial/anti-biofilm agent. The heparinized nanosilver showed good blood compatibility and strong inhibitory/eradicating effects on microbial biofilms.
Catheter-related bloodstream infections (CRBSI) are the major concern of patients undergoing hemodialysis. The current study formulates bifunctional low molecular weight heparin (LMWH) coated nanosilver as an effective anticoagulant and antimicrobial/anti-biofilm agent. Nanosilver formulations were prepared using a microwave-assisted green synthesis approach and stabilized with pharmaceutically approved LMWH such as dalteparin (DL) and enoxaparin (EX) along with unfractionated heparin (HP) as a control. The obtained heparinized (HP/DL/EX) nanosilver was monodisperse, and the size ranged between 15 and 25 nm. DL/EX predominantly stabilized the nanosilver by primarily engaging their negatively charged sulfate groups. The obtained DL/EX coated nanosilver are hemocompatible, showed two times increase in their anticoagulation activity, and are highly potent in inhibiting/eradicating both mono- and polymicrobial biofilms. Henceforth, the observed biocompatible and enhanced bifunctional characteristics of DL/EX coated nanosilver can be used to replace the systemic antibiotics and can be an alternative catheter lock solution to prevent CRBSI in hemodialysis therapy.
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