期刊
CARBOHYDRATE POLYMERS
卷 294, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119778
关键词
Acrylic acid; Bacterial cellulose nanofibers; Biocompatible hydrogel; Double network
资金
- Spanish Ministry of Science and Innovation [RTI2018-096273-B-I00, PID2021-122645OB-100]
- 'Severo Ochoa' Programme for Center of Excellence in RD [CEX2019-000917]
- Generalitat de Catalunya [2017SGR765]
- Ministry of Science Technology and Space of Israel [3-15638]
- UAB [PRE2019-089754]
Acrylate hydrogels are potential soft tissue implants, but their weak mechanical properties and dimensional changes in liquids limit their applications. By fabricating double network hydrogels, the mechanical properties and swelling behavior of acrylate hydrogels can be improved.
Soft-tissue replacements are challenging due to the stringent compliance requirements for the implanted materials in terms of biocompatibility, durability, high wear resistance, low friction, and water content. Acrylate hydrogels are worth considering as soft tissue implants as they can be photocurable and sustain customized shapes through 3D bioprinting. However, acrylate-based hydrogels present weak mechanical properties and significant dimensional changes when immersed in liquids. To address these obstacles, we fabricated double network (DN) hydrogels composed of polyacrylic acid (PAA) and bacterial cellulose nanofibers (BCNFs) by one fast UV photopolymerization step. BCNFs/PAA hydrogels with a 0.5 wt% BCNFs content present an increased stiffness and a lower, non-pH-dependent swelling than PAA hydrogels or PAA hydrogels with cellulose nanocrystals. Besides, BCNFs/PAA hydrogels are biocompatible and can be frozen/thawed. Those characteristics endorse these hybrid hydrogels as potential candidates for vascular and cartilage tissue implants.
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