4.7 Article

Alginate-based hydrogel fiber as a restricted access material for microextraction of drugs in biological samples

期刊

CARBOHYDRATE POLYMERS
卷 294, 期 -, 页码 -

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ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119810

关键词

Hydrogel; Alginate; Restricted access material; HPLC; Microextraction; Human plasma

资金

  1. CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
  2. CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)

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A novel alginate-based hydrogel device was successfully prepared and applied for solid-phase microextraction of drugs in human plasma, showing high extraction efficiency and precision. This concept has not been explored in previous literature.
A novel lab-made alginate-based hydrogel device was successfully prepared and applied as a sorption material for the solid-phase microextraction of drugs (fluoxetine and its metabolite, norfluoxetine) in human plasma, with subsequent determination by high performance liquid chromatography-fluorescence detection (HPLC-FD). When supported in a polypropylene hollow fiber, the alginate was able to extract the analytes and functioned as a restricted access material, excluding >95 % of proteins from the biological matrix. The results indicate the potential use of this phase/device for quantitative drugs extraction from biological matrices at concentrations compatible with those typical in the literature (0.5 mu g mL-1), and with satisfactory precision (13.4 % for fluoxetine and 6.2 % for norfluoxetine). Such outcomes, promoted by a simple and inexpensive material, open a new perspective of exploration of hydrogels as the sorption phase in biological matrices, a concept previously unexplored in the literature.

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