4.7 Article

Study on repair of abdominal wall defect rats with hernia mesh coated with chitosan-based photosensitive hydrogel

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CARBOHYDRATE POLYMERS
卷 291, 期 -, 页码 -

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ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119577

关键词

Chitosan; Photosensitive; Hydrogel; Hernia repair

资金

  1. Key R&D Program of Shandong Province [2021CXGC010502]

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This study synthesized hydroxypropyl chitosan azide and applied it as a hydrogel coating on a polypropylene mesh. The hydrogel exhibited excellent biocompatibility and biodegradability, and adhered well to the mesh. During the 180-day follow-up period, the coated mesh promoted wound healing by stimulating the secretion of transforming growth factor-beta1. The coated mesh also showed improved fibrin lysozyme activity and reduced intraperitoneal adhesion compared to the uncoated mesh.
Herein, hydroxypropyl chitosan azide (AZ-HPCTS) was synthesized and prepared as a hydrogel coating applied to a polypropylene mesh (PPM) through UV irradiation. This study confirmed the hypothesis that hydrogels with porous three-dimensional network structures exhibited excellent biocompatibility and biodegradability and adhered well to PPM. During the 180-day follow-up period, the AZ-HPCTS-coated PPM (AH-PPM) promoted wound healing by promoting the secretion of transforming growth factor-beta1 (TGF-beta1) in the acute reaction stage, which was reduced to a lower level at 30 d. The PPM exhibited a lower fibrin lysozyme activity based on the expression of tissue plasminogen activator (tPA) compared with that of AH-PPM (P < 0.05). The intraperitoneal adhesion score of AH-PPM decreased to 2.4 at 180 d in contrast with PPM (P < 0.01), which remained at a high level throughout the study. In conclusion, the AZ-HPCTS hydrogel is a potential coating for hernia patches that deserves further study in the biomaterial field.

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