期刊
CARBOHYDRATE POLYMERS
卷 294, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119767
关键词
N-succinyl chitosan; Oxidized hyaluronic acid; Calcium ions; Hemostasis; Wound healing
资金
- Technology Development Projectof Shandong Province of China [2017GSF18119]
- National Natural Science Foundation of China [YDZX20203700002579]
- Central Government Guide Local Science and Technology Development Funds
- Life Science & Environment General Research Technology Platform of Shandong University
Novel NSC-OHA-based hydrogels with self-healing and injectable properties were fabricated, and the mechanical behavior and bioactivities were regulated by the addition of Ca2+ or PEG1. The hydrogels showed improved biocompatibility, hemostasis, and wound healing abilities, making them promising for medical applications.
It is a challenge to develop hemostatic and wound dressings that are used for irregular shape and deep wound. Herein, a series of novel N-succinyl chitosan-oxidized hyaluronic acid based (NSC-OHA-based) hydrogels were fabricated, while calcium ions (Ca2+) and/or four-armed amine-terminated poly(ethylene glycol) (4-arm-PEG-NH2, labeled as PEG1) were introduced to regulate the mechanical behavior and bioactivities. We found all NSC-OHA-based hydrogels displayed self-healing and injectable performances. Besides, the addition of Ca2+ or PEG1 exhibited a positive effect on the adjustable mechanical behavior of hydrogels, providing the possibility to meet different mechanical requirements. Furthermore, Ca2+ or PEG1 significantly improved the biocompatibility, hemostasis and wound healing abilities of NSC-OHA hydrogel. Notably, compared with the commercial hemostatic agent (AristaTM), hydrogels containing Ca2+ showed comparable hemostatic effects and significantly accelerated wound healing. Overall, the calcium-containing NSC-OHA hydrogels are promising for hemostasis and accelerating wound healing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据