期刊
CARBOHYDRATE POLYMERS
卷 291, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119626
关键词
Lycium barbarum L; Polysaccharides; Gut microbiota; Barrier function; Hypoglycemic activity
资金
- Key Research and Development Project funded by Ningxia Hui Autonomous Region of China [2021BEF02008, 2019BFG02026]
- National Natural Science Foun-dation of China [31860083]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
The study found that polysaccharides from the fruits of Lycium barbarum L. (LBPs) can improve blood glucose levels and beta-cell function in diabetic mice by modulating gut microbiota and protecting intestinal barrier function.
The antidiabetic effect and potential mechanisms of the polysaccharides from the fruits of Lycium barbarum L. (LBPs) by the mouse model of high-fat diet/streptozotocin-induced diabetes were investigated. Six-week oral administration of LBPs (200 mg/kg/day) resulted in improvement in the levels of fasting blood glucose (13.51% decrease) and glycated hemoglobin and beta-cell function in diabetic mice, and simultaneously induced a 3.3-fold increment in one taxon belonging to genus Allobaculum in gut bacterial community. The experiments of fecal microbiota transplantation and antibiotics treatment confirmed that the LBPs-mediated gut microbiota participated in the glycemic control of the diabetes management. Moreover, LBPs intervention guarded the intestinal barrier function via upregulating the expression of zonula occludens 1 both in vivo (analyzing the gut permeability in diabetic mice) and in vitro (using intestinal-like Caco-2/RAW264.7 cells co-culture inflammation model). Collectively, our study showed that LBPs could confer anti-diabetic effect through modifying gut microbiota and intestinal barrier.
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